The septic heart: current understanding of molecular mechanisms and clinical implications

L Martin, M Derwall, S Al Zoubi, E Zechendorf… - Chest, 2019 - Elsevier
Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. Despite
the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation …

Vasopressor therapy in critically ill patients with shock

JA Russell - Intensive care medicine, 2019 - Springer
Background Vasopressors are administered to critically ill patients with vasodilatory shock
not responsive to volume resuscitation, and less often in cardiogenic shock, and …

Which multicenter randomized controlled trials in critical care medicine have shown reduced mortality? A systematic review

CA Santacruz, AJ Pereira, E Celis… - Critical care …, 2019 - journals.lww.com
Objectives: To determine which multicenter randomized controlled trials in critically ill
patients have shown that the study intervention was associated with a statistically significant …

Shock–classification and pathophysiological principles of therapeutics

ON Kislitsina, JD Rich, JE Wilcox… - Current cardiology …, 2019 - ingentaconnect.com
The management of patients with shock is extremely challenging because of the myriad of
possible clinical presentations in cardiogenic shock, septic shock and hypovolemic shock …

Inotropes and vasopressors use in cardiogenic shock: when, which and how much?

B Levy, J Buzon, A Kimmoun - Current opinion in critical care, 2019 - journals.lww.com
When blood pressure needs to be restored, norepinephrine is a reasonable first-line agent.
Dobutamine is the first-line inotrope agent wheraes levosimendan can be used as a second …

Automated Titration of Vasopressor Infusion Using a Closed-loop Controller: In Vivo Feasibility Study Using a Swine Model

A Joosten, A Delaporte, B Alexander, F Su… - …, 2019 - pubs.asahq.org
Abstract Editor's Perspective What We Already Know about This Topic Intraoperative
hypotension has been associated with adverse postoperative outcomes. A randomized …

Comparative efficacy of vasoactive medications in patients with septic shock: a network meta-analysis of randomized controlled trials

L Cheng, J Yan, S Han, Q Chen, M Chen, H Jiang, J Lu - Critical care, 2019 - Springer
Background Catecholamines, especially norepinephrine, are the most frequently used
vasopressors for treating patients with septic shock. During the recent decades, terlipressin …

Vasoactive agent use in septic shock: beyond first‐line recommendations

GL Sacha, SR Bauer, I Lat - Pharmacotherapy: The Journal of …, 2019 - Wiley Online Library
Septic shock is a life‐threatening disorder associated with high mortality rates requiring
rapid identification and intervention. Vasoactive agents are often required to maintain goal …

Closed-loop vasopressor control: in-silico study of robustness against pharmacodynamic variability

J Rinehart, A Joosten, M Ma, MD Calderon… - Journal of clinical …, 2019 - Springer
Initial feasibility of a novel closed-loop controller created by our group for closed-loop control
of vasopressor infusions has been previously described. In clinical practice, vasopressor …

Translational gap in pediatric septic shock management: an ESPNIC perspective

L Morin, M Kneyber, NJG Jansen, MJ Peters… - Annals of Intensive …, 2019 - Springer
Abstract Background The Surviving Sepsis Campaign and the American College of Critical
Care Medicine guidelines have provided recommendations for the management of pediatric …