A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages

Y Feng, R Mu, Z Wang, P Xing, J Zhang, L Dong… - Nature …, 2019 - nature.com
Switching macrophages from a pro-tumor type to an anti-tumor state is a promising strategy
for cancer immunotherapy. Existing agents, many derived from bacterial components, have …

TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro

MA Ezz, MA Marey, AE Elweza, T Kawai… - PLoS …, 2019 - journals.plos.org
We have recently shown that sperm attachment to bovine endometrial epithelial cells
(BEECs) triggers uterine local innate immunity with induction of a pro-inflammatory response …

TLR1/2 specific small‐molecule agonist suppresses leukemia cancer cell growth by stimulating cytotoxic T lymphocytes

X Cen, G Zhu, J Yang, J Yang, J Guo, J Jin… - Advanced …, 2019 - Wiley Online Library
Abstract Toll‐like receptor 2 (TLR2) expressed on antigen presenting cells evokes a series
of critical cytokines, which favor the development of tumor‐specific cytotoxic T lymphocytes …

Triptolide inhibits preformed fibril‐induced microglial activation by targeting the MicroRNA155‐5p/SHIP1 pathway

Y Feng, C Zheng, Y Zhang, C Xing… - Oxidative medicine …, 2019 - Wiley Online Library
Evidence suggests that various forms of α‐synuclein‐(αSyn‐) mediated microglial activation
are associated with the progression of Parkinson's disease. MicroRNA‐155‐5p (miR155 …

Модулирование локальной экспрессии факторов врожденного иммунитета у пациенток с хроническим эндометритом и бесплодием

ЮЭ Доброхотова, ЛВ Ганковская… - Акушерство и …, 2019 - elibrary.ru
Материал и методы. 43 пациентки с хроническим эндометритом (основная группа), 15
здоровых женщин (группа сравнения). Материал эндометрия получен путем …

Perturbation of normal algal growth by black phosphorus nanosheets: the role of degradation

P Li, L Zeng, J Gao, L Yao, X Zhao, Q Wu… - … & Technology Letters, 2019 - ACS Publications
Due to potential applications of black phosphorus nanosheets (BPNSs) in many fields in the
near future, the toxicological effects of BPNSs on environmental organisms is becoming a …

TLR1/2 orchestrate human plasmacytoid predendritic cell response to gram+ bacteria

S Raieli, C Trichot, S Korniotis, L Pattarini… - PLoS …, 2019 - journals.plos.org
Gram+ infections are worldwide life-threatening diseases in which the pathological role of
type I interferon (IFN) has been highlighted. Plasmacytoid predendritic cells (pDCs) produce …

Identification and immunological evaluation of novel TLR2 agonists through structure optimization of Pam3CSK4

X Du, J Qian, Y Wang, M Zhang, Y Chu, Y Li - Bioorganic & Medicinal …, 2019 - Elsevier
Abstract Toll-like receptor 2 (TLR2) is a bridge between innate immunity and adaptive
immunity. TLR2 agonists have been exploited as potential vaccine adjuvants and antitumor …

Identification and characterization of a novel chemotype for human TLR8 inhibitors

D Šribar, M Grabowski, MS Murgueitio… - European journal of …, 2019 - Elsevier
The endosomal Toll-like receptor 8 (TLR8) recognizes single-stranded RNA and initiates
early inflammatory responses. Despite the importance of endosomal TLRs for human host …

Structure-activity relationship study and biological evaluation of SAC-Garlic acid conjugates as novel anti-inflammatory agents

J Bi, W Wang, J Du, K Chen, K Cheng - European Journal of Medicinal …, 2019 - Elsevier
A series of S-allyl-l-cysteine (SAC) with garlic acid conjugates as anti-inflammatory agents
were designed and synthesized. Among the 40 tested compounds, SMU-8c exhibited the …