Analogues of desferrioxamine B (DFOB) with new properties and new functions generated using precursor-directed biosynthesis

TJ Telfer, T Richardson-Sanchez, MP Gotsbacher… - Biometals, 2019 - Springer
Desferrioxamine B (DFOB) is a siderophore native to Streptomyces pilosus biosynthesised
by the DesABCD enzyme cluster as a high affinity Fe (III) chelator. Although DFOB has a …

Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis

Y Martínez-Burgo, J Santos-Aberturas… - Frontiers in …, 2019 - frontiersin.org
Expression of non-native transcriptional activators may be a powerful general method to
activate secondary metabolites biosynthetic pathways. PAS-LuxR regulators, whose …

Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight Into Specialized Metabolism

NF AbuSara, BM Piercey, MA Moore… - Frontiers in …, 2019 - frontiersin.org
Clavulanic acid is a bacterial specialized metabolite, which inhibits certain serine β-
lactamases, enzymes that inactivate β-lactam antibiotics to confer resistance. Due to this …

Siderophore profiling of co-habitating soil bacteria by ultra-high resolution mass spectrometry

RM Boiteau, SJ Fansler, Y Farris, JB Shaw… - Metallomics, 2019 - academic.oup.com
The chemical structure of organic molecules profoundly impacts their interactions with metal
ions and mineral phases in soils. Understanding the sources and cycling of metal-chelating …

Legonoxamines AB, two new hydroxamate siderophores from the soil bacterium, Streptomyces sp. MA37

F Maglangit, MH Tong, M Jaspars, K Kyeremeh… - Tetrahedron …, 2019 - Elsevier
Two new siderophores belonging to the hydroxamate class, Legonoxamine A (1) and B (2)
have been isolated from the soil bacterium, Streptomyces sp. MA37, together with one …

Complete genome sequences of Streptomyces spp. isolated from disease-suppressive soils

SC Heinsch, SY Hsu, L Otto-Hanson, L Kinkel… - BMC genomics, 2019 - Springer
Background Bacteria within the genus Streptomyces remain a major source of new natural
product discovery and as soil inoculants in agriculture where they promote plant growth and …

A suite of asymmetric citrate siderophores isolated from a marine Shewanella species

JR Carmichael, H Zhou, A Butler - Journal of Inorganic Biochemistry, 2019 - Elsevier
Woodybactins AD are a suite of new fatty acyl siderophores produced by the luminous
marine bacterium Shewanella woodyi MS32. While this bacterium has a set of genes …

An isotopic ratio outlier analysis approach for global metabolomics of biosynthetically talented actinomycetes

J Carey, T Nguyen, J Korchak, C Beecher, F De Jong… - Metabolites, 2019 - mdpi.com
Actinomycetes are powerhouses of natural product biosynthesis. Full realization of this
biosynthetic potential requires approaches for recognizing novel metabolites and …

Streptomyces corynorhini sp. nov., isolated from Townsend's big-eared bats (Corynorhinus townsendii)

PS Hamm, NA Caimi, DE Northup, EW Valdez… - Antonie Van …, 2019 - Springer
Four bacterial strains, with the capability of inhibiting Pseudogymnoascus destructans, the
causative agent of white-nose syndrome, were isolated from male Townsend's big-eared …

Complete Genome Sequence of the Putative Phosphonate Producer Streptomyces sp. Strain I6, Isolated from Indonesian Mangrove Sediment

J Krause, S Ratnakomala, P Lisdiyanti… - Microbiology …, 2019 - Am Soc Microbiol
Streptomyces sp. strain I6 is a novel strain isolated from an Indonesian mangrove sediment
sample. Bioinformatic analysis of the genome sequence of Streptomyces sp. I6 revealed 23 …