The role of miRNAs in the invasion and metastasis of cervical cancer

J Wang, L Chen - Bioscience reports, 2019 - portlandpress.com
Cervical cancer (CC) with early metastasis of the primary tumor results in poor prognosis
and poor therapeutic outcomes. MicroRNAs (miRNAs) are small, noncoding RNA molecules …

Genome‐wide association studies and polygenic risk scores for skin cancer: clinically useful yet?

MR Roberts, MM Asgari… - British Journal of …, 2019 - academic.oup.com
Background Genome‐wide association studies (GWAS) have identified thousands of
susceptibility variants, although most have been associated with small individual risk …

Mendelian Randomization and mediation analysis of leukocyte telomere length and risk of lung and head and neck cancers

L Kachuri, O Saarela, SE Bojesen… - International journal …, 2019 - academic.oup.com
Background Evidence from observational studies of telomere length (TL) has been
conflicting regarding its direction of association with cancer risk. We investigated the causal …

Hereditary prostate cancer–Primetime for genetic testing?

I Heidegger, I Tsaur, H Borgmann, C Surcel… - Cancer treatment …, 2019 - Elsevier
Prostate cancer (PCa) remains the most common cancer in men. The proportion of all PCa
attributable to high-risk hereditary factors has been estimated to 5–15%. Recent landmark …

[HTML][HTML] Telomerase and telomeres in endometrial cancer

RAA Alnafakh, M Adishesh, L Button, G Saretzki… - Frontiers in …, 2019 - frontiersin.org
Telomeres at the termini of human chromosomes are shortened with each round of cell
division due to the “end replication problem” as well as oxidative stress. During …

[HTML][HTML] Nasopharyngeal cancer in Saudi Arabia: Epidemiology and possible risk factors

AD Alotaibi, HG Ahmed, AM Elasbali - Journal of Oncological Sciences, 2019 - Elsevier
Abstract Although, Nasopharyngeal Carcinoma (NPC) is uncommon in Arab countries, but
its incidence is raising due to increased exposure to diverse risk factors. Many of the NPC …

TERT rs10069690 polymorphism and cancers risk: A meta‐analysis

G He, T Song, Y Zhang, X Chen… - Molecular genetics & …, 2019 - Wiley Online Library
Background Studies have identified that the telomerase reverse transcriptase (TERT) gene
polymorphism rs10069690 (C> T) is associated with cancer risk, but the results remain …

Cutaneous keratinocyte cancers of the head and neck: epidemiology, risk factors and clinical, dermoscopic and reflectance confocal microscopic features

KJ Lee, HP Soyer - Oral Oncology, 2019 - Elsevier
Keratinocyte cancers are the most common malignancy among people with European
ancestry, and are very common on sun-exposed areas of the head and neck. Incidence is …

Investigation of leukocyte telomere length and genetic variants in chromosome 5p15. 33 as prognostic markers in lung cancer

L Kachuri, J Helby, SE Bojesen, DC Christiani… - … Biomarkers & Prevention, 2019 - AACR
Background: Lung cancer remains the leading cause of cancer mortality with relatively few
prognostic biomarkers. We investigated associations with overall survival for telomere length …

Functional polymorphisms on chromosome 5p15. 33 disturb telomere biology and confer the risk of non‐small cell lung cancer in Chinese population

Y Li, C Xiang, N Shen, L Deng, X Luo… - Molecular …, 2019 - Wiley Online Library
The chromosome 5p15. 33 has been reported as a susceptibility locus for lung cancer.
However, causal variants in this region have not been fully uncovered. In this study, we …