Ischemic stroke is a leading cause of morbidity and mortality worldwide. Resident microglia
are the principal immune cells of the brain, and the first to respond to the pathophysiological …

Circular RNAs (circRNAs) are expressed at high levels in the brain and are involved in
various CNS diseases. However, the potential role of circRNAs in ischemic stroke …

ABSTRACT Introduction: The Notch pathway is involved in determining cell fate during
development and postnatally in continuously renewing tissues, such as the endothelium, the …

Background Remote ischemic preconditioning (RIPC) initiates endogenous protective
pathways in the brain from a distance and represents a new, promising paradigm in …

Background Activated microglia-mediated neuroinflammation has been regarded as an
underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced …

Diabetic foot ulcerations (DFUs) represent a major medical, social, and economic problem.
Therapeutic options are restricted due to a poor understanding of the pathogenic …

Recent studies revealed that folic acid deficiency (FD) increased the likelihood of stroke and
aggravated brain injury after focal cerebral ischaemia. The microglia‐mediated inflammatory …

Cerebral stroke is one of the leading causes of death and permanent disability worldwide.
Toll-like receptor 4 (TLR4) and nuclear factor-kappa B (NF-κB) p65 play a critical role in …

Microglial cells are resident immune cells and play an important role in various cerebral and
retinal inflammatory diseases. Notch1 signaling is involved in the microglia polarization and …

As an inhibitor of the Notch signaling pathway, N-[N-(3, 5-difluorohenacetyl)-l-alanyl]-S-
phenylglycine tert-butyl ester (DAPT) may protect brain tissue from serious ischemic injury …