Little is still known about the neuroanatomical substrates related to changes in specific
cognitive abilities in the course of healthy aging, and the existing evidence is predominantly …

Population-based clinic-pathological studies have established that the most common
pathological substrate of dementia in community-dwelling elderly people is mixed …

Background Nine potentially modifiable risk factors (less childhood education, midlife
hearing loss, hypertension, and obesity, and later-life smoking, depression, physical …

Objective To examine whether physical inactivity is a risk factor for dementia, with attention
to the role of cardiometabolic disease in this association and reverse causation bias that …

This article describes the public health impact of Alzheimer's disease (AD), including
incidence and prevalence, mortality and morbidity, use and costs of care, and the overall …

Background Information from well-established dementia risk models can guide targeted
intervention to prevent dementia, in addition to the main purpose of quantifying the …

Vascular contributions to cognitive impairment and dementia (VCID) is the second most
common cause of dementia. While males overall appear to be at a slightly higher risk for …

Objectives To examine the association between the Life Simple 7 cardiovascular health
score at age 50 and incidence of dementia. Design Prospective cohort study. Setting Civil …

The older Finnish Twin Cohort (FTC) was established in 1974. The baseline survey was in
1975, with two follow-up health surveys in 1981 and 1990. The fourth wave of assessments …

Obesity has been associated with cognitive and behavioral syndromes. Individuals who are
obese have higher risk for developing neuropsychiatric disorders such as depression and …