[HTML][HTML] FOXO3 on the road to longevity: lessons from SNPs and chromatin hubs
P Sanese, G Forte, V Disciglio, V Grossi… - Computational and …, 2019 - Elsevier
Health span is driven by a precise interplay between genes and the environment. Cell
response to environmental cues is mediated by signaling cascades and genetic variants that …
response to environmental cues is mediated by signaling cascades and genetic variants that …
DNA methylation of enhancer elements in myeloid neoplasms: think outside the promoters?
Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …
prominent role in physiological and pathological cell-states. This epigenetic modification is …
RegulationSpotter: annotation and interpretation of extratranscriptic DNA variants
JM Schwarz, D Hombach, S Köhler… - Nucleic Acids …, 2019 - academic.oup.com
RegulationSpotter is a web-based tool for the user-friendly annotation and interpretation of
DNA variants located outside of protein-coding transcripts (extratranscriptic variants). It is …
DNA variants located outside of protein-coding transcripts (extratranscriptic variants). It is …
From enhanceropathies to the epigenetic manifold underlying human cognition
A vast portion of intellectual disability and autism spectrum disorders is genetically caused
by mutations in chromatin modulators. These proteins play key roles in development and are …
by mutations in chromatin modulators. These proteins play key roles in development and are …
Expression of TMBIM6 in cancers: the involvement of Sp1 and PKC
RP Junjappa, HK Kim, SY Park, KR Bhattarai, KW Kim… - Cancers, 2019 - mdpi.com
Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) is upregulated in several cancer
types and involved in the metastasis. Specific downregulation of TMBIM6 results in cancer …
types and involved in the metastasis. Specific downregulation of TMBIM6 results in cancer …
Genome-wide identification of enhancer elements in the placenta
Normal placental development is essential for a healthy pregnancy, and is contingent upon
tight spatiotemporal regulation of gene expression. One level of transcriptional control is via …
tight spatiotemporal regulation of gene expression. One level of transcriptional control is via …
Efficiently searching for enhancers and their target genes in the human genome
MJ Gasperini - 2019 - digital.lib.washington.edu
A single 3 billion letter genome contains the instructions for the 37 trillion diverse cells that
make up one human. To accomplish this, the~ 21,000 human genes are expressed and …
make up one human. To accomplish this, the~ 21,000 human genes are expressed and …
[PDF][PDF] Clinical implications of DNA methylation for kidney transplantation
F Peters - 2019 - repub.eur.nl
The main objective of this thesis is to explore the role of DNA methylation changes in
complications after kidney transplantation. To answer this two complementary approaches …
complications after kidney transplantation. To answer this two complementary approaches …
DNA methylation of enhancer elements in myeloid neoplasms: think outside the promoters?
N Martinez-Calle, X Aguirre-Ena, F Prosper-Cardoso - 2019 - dadun.unav.edu
Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …
prominent role in physiological and pathological cell-states. This epigenetic modification is …