Health span is driven by a precise interplay between genes and the environment. Cell
response to environmental cues is mediated by signaling cascades and genetic variants that …

Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …

RegulationSpotter is a web-based tool for the user-friendly annotation and interpretation of
DNA variants located outside of protein-coding transcripts (extratranscriptic variants). It is …

A vast portion of intellectual disability and autism spectrum disorders is genetically caused
by mutations in chromatin modulators. These proteins play key roles in development and are …

Transmembrane Bax Inhibitor Motif-containing 6 (TMBIM6) is upregulated in several cancer
types and involved in the metastasis. Specific downregulation of TMBIM6 results in cancer …

Normal placental development is essential for a healthy pregnancy, and is contingent upon
tight spatiotemporal regulation of gene expression. One level of transcriptional control is via …

A single 3 billion letter genome contains the instructions for the 37 trillion diverse cells that
make up one human. To accomplish this, the~ 21,000 human genes are expressed and …

The main objective of this thesis is to explore the role of DNA methylation changes in
complications after kidney transplantation. To answer this two complementary approaches …

Gene regulation through DNA methylation is a well described phenomenon that has a
prominent role in physiological and pathological cell-states. This epigenetic modification is …