Aspergillus fumigatus is a saprotrophic fungus; its primary habitat is the soil. In its ecological
niche, the fungus has learned how to adapt and proliferate in hostile environments. This …

Aspergillus flavus is the second most common etiological agent of invasive aspergillosis (IA)
after A. fumigatus. However, most literature describes IA in relation to A. fumigatus or …

Background Fungal diseases range from relatively-minor superficial and mucosal infections
to severe, life-threatening systemic infections. Delayed diagnosis and treatment can lead to …

These updated AST‐IDCOP guidelines provide information on epidemiology, diagnosis, and
management of Aspergillus after organ transplantation. Aspergillus is the most common …

Background Triazole resistance is an increasing problem in invasive aspergillosis (IA).
Small case series show mortality rates of 50%–100% in patients infected with a triazole …

CYP51 (Erg11) belongs to the cytochrome P450 monooxygenase (CYP) superfamily and
mediates a crucial step of the synthesis of ergosterol, which is a fungal-specific sterol. It is …

Background Metagenomic next-generation sequencing (mNGS) is emerging as a promising
technique for pathogens detection. However, reports on the application of mNGS in mixed …

Breakthrough invasive fungal infections (IFI s) have emerged as a significant problem in
patients receiving systemic antifungals; however, consensus criteria for defining …

Abstract Background Triazole resistance in Aspergillus fumigatus is widespread and
threatens first-line triazole therapy in patients with Aspergillus diseases. Objectives To give …

Chronic pulmonary aspergillosis (CPA) complicates treated pulmonary tuberculosis (TB),
with high 5-year mortality. We measured CPA prevalence in this group. 398 Ugandans with …