Autophagy, a self-digestion intracellular catabolic process, plays a crucial role in cellular
homeostasis under conditions of starvation, oxidative stress and genotoxic stress. The …

Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma
lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects …

The multifunctional signaling hub p62 is well recognized as a ubiquitin sensor and a
selective autophagy receptor. As a ubiquitin sensor, p62 promotes NFΚB activation by …

The biological characteristics of bladder cancer include enhanced invasion and migration,
which are the main causes of death in patients. Starvation is a typical feature of the bladder …

DNA damage response (DDR) and selective autophagy both can be activated by reactive
oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in cancer …

Post-translational modifications directly control protein activity and, thus, they represent an
important means to regulate the responses of cells to different stimuli. Protein SUMOylation …

Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that
accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis‐R) display …

Approximately half of high-risk neuroblastoma is characterized by MYCN amplification. N-
Myc promotes tumor progression by inducing cell growth and inhibiting differentiation …

Background Increasing evidence has validated the crucial role of alternative splicing (AS) in
tumors. However, comprehensive investigations on the entirety of AS and their clinical value …

Timosaponin A-III (TAIII) is a saponin isolated from anemarrhena asphodeloides and
possesses the inhibitory effect on proliferation of multiple tumor cells. In the present study …