[HTML][HTML] The dual roles of autophagy in gliomagenesis and clinical therapy strategies based on autophagic regulation mechanisms
F Feng, M Zhang, C Yang, X Heng, X Wu - Biomedicine & Pharmacotherapy, 2019 - Elsevier
Autophagy, a self-digestion intracellular catabolic process, plays a crucial role in cellular
homeostasis under conditions of starvation, oxidative stress and genotoxic stress. The …
homeostasis under conditions of starvation, oxidative stress and genotoxic stress. The …
Autophagic flux disruption contributes to Ganoderma lucidum polysaccharide-induced apoptosis in human colorectal cancer cells via MAPK/ERK activation
H Pan, Y Wang, K Na, Y Wang, L Wang, Z Li… - Cell death & …, 2019 - nature.com
Targeting autophagy may serve as a promising strategy for cancer therapy. Ganoderma
lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects …
lucidum polysaccharide (GLP) has been shown to exert promising anti-cancer effects …
The multifunctional protein p62 and its mechanistic roles in cancers
S Ning, L Wang - Current cancer drug targets, 2019 - ingentaconnect.com
The multifunctional signaling hub p62 is well recognized as a ubiquitin sensor and a
selective autophagy receptor. As a ubiquitin sensor, p62 promotes NFΚB activation by …
selective autophagy receptor. As a ubiquitin sensor, p62 promotes NFΚB activation by …
Starvation‐induced autophagy promotes the invasion and migration of human bladder cancer cells via TGF‐β1/Smad3‐mediated epithelial‐mesenchymal transition …
H Tong, H Yin, MA Hossain, Y Wang… - Journal of cellular …, 2019 - Wiley Online Library
The biological characteristics of bladder cancer include enhanced invasion and migration,
which are the main causes of death in patients. Starvation is a typical feature of the bladder …
which are the main causes of death in patients. Starvation is a typical feature of the bladder …
p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress
L Wang, MEA Howell, A Sparks-Wallace… - PLoS …, 2019 - journals.plos.org
DNA damage response (DDR) and selective autophagy both can be activated by reactive
oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in cancer …
oxygen/nitrogen species (ROS/RNS), and both are of paramount importance in cancer …
Inhibiting SUMO1-mediated SUMOylation induces autophagy-mediated cancer cell death and reduces tumour cell invasion via RAC1
M Lorente, A García-Casas, N Salvador… - Journal of Cell …, 2019 - journals.biologists.com
Post-translational modifications directly control protein activity and, thus, they represent an
important means to regulate the responses of cells to different stimuli. Protein SUMOylation …
important means to regulate the responses of cells to different stimuli. Protein SUMOylation …
Targeting V‐ATPase isoform restores cisplatin activity in resistant ovarian cancer: inhibition of autophagy, endosome function, and ERK/MEK pathway
A Kulshrestha, GK Katara, SA Ibrahim… - Journal of …, 2019 - Wiley Online Library
Ovarian cancer (OVCA) patients often develop tolerance to standard platinum therapy that
accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis‐R) display …
accounts for extensive treatment failures. Cisplatin resistant OVCA cells (cis‐R) display …
A novel MYCN-specific antigene oligonucleotide deregulates mitochondria and inhibits tumor growth in MYCN-amplified neuroblastoma
L Montemurro, S Raieli, S Angelucci, D Bartolucci… - Cancer research, 2019 - AACR
Approximately half of high-risk neuroblastoma is characterized by MYCN amplification. N-
Myc promotes tumor progression by inducing cell growth and inhibiting differentiation …
Myc promotes tumor progression by inducing cell growth and inhibiting differentiation …
Role of alternative splicing signatures in the prognosis of glioblastoma
Z Xie, H Wu, Y Dang, G Chen - Cancer medicine, 2019 - Wiley Online Library
Background Increasing evidence has validated the crucial role of alternative splicing (AS) in
tumors. However, comprehensive investigations on the entirety of AS and their clinical value …
tumors. However, comprehensive investigations on the entirety of AS and their clinical value …
Timosaponin A-III induces autophagy of T-cell acute lymphoblastic leukemia Jurkat cells via inhibition of the PI3K/Akt/mTOR pathway
H Wang, R Dong, WW Fan, XC Zheng… - Oncology …, 2019 - spandidos-publications.com
Timosaponin A-III (TAIII) is a saponin isolated from anemarrhena asphodeloides and
possesses the inhibitory effect on proliferation of multiple tumor cells. In the present study …
possesses the inhibitory effect on proliferation of multiple tumor cells. In the present study …