The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide
range of immunologic functions alongside its roles in hematopoiesis and red blood cell …

The initiation of T lymphocyte responses within secondary lymphoid organs involves
interactions with different subsets of dendritic cells (DC s). Recent studies have revealed the …

Aging of established antiviral T cell memory can foster a series of progressive adaptations
that paradoxically improve rather than compromise protective CD8+ T cell immunity. We now …

ABSTRACT A large proportion of the world population harbors herpes simplex virus 1 (HSV-
1), a major cause of infectious corneal blindness. HSV-specific CD8+ T cells protect from …

It is common practice for researchers to use antibodies to remove a specific cell type to infer
its function. However, it is difficult to completely eliminate a cell type and there is often limited …

Allergic patients have life-long chronic inflammatory diseases with repeated relapses and
exacerbations. Currently used allergy therapeutics have some limitations, which warrants a …

In this study we identified that restricting pyrimidine levels through pharmacological
treatment with leflunomide early during T cell activation blocks the differentiation of CD8+ …