Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …

Regulated cell death is a major mechanism to eliminate damaged, infected, or superfluous
cells. Previously, apoptosis was thought to be the only regulated cell death mechanism; …

Rationale: Idiopathic pulmonary fibrosis (IPF) causes considerable global morbidity and
mortality, and its mechanisms of disease progression are poorly understood. Recent …

The deiodinase family of enzymes mediates the activation and inactivation of thyroid
hormone. The role of these enzymes in the regulation of the systemic concentrations of …

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease where invasive
pulmonary myofibroblasts secrete collagen and destroy lung integrity. Here, we show that …

Cellular senescence is a biological process by which cells lose their capacity to proliferate
yet remain metabolically active. Although originally considered a protective mechanism to …

The lung is often overlooked as a metabolically active organ, yet biochemical studies have
long demonstrated that glucose utilization surpasses that of many other organs, including …

To develop a systems biology model of fibrosis progression within the human lung we
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 …

This is a time of substantial progress in the evaluation and care of patients with idiopathic
pulmonary fibrosis (IPF). In addition to the approval and widespread availability of the first …

Abstract Background Vitamin D (VitD) is a steroid hormone with cytoprotective and anti-
inflammatory properties. Epidemiological studies have suggested a link between VitD …