Gene therapy as a strategy for disease treatment requires safe and efficient gene delivery
systems that encapsulate nucleic acids and deliver them to effective sites in the cell. Due to …

Transfection is a process by which oligonucleotides (DNA or RNA) are delivered into living
cells. This allows the synthesis of target proteins as well as their inhibition (gene silencing) …

Prostate cancer is one of the most common malignant tumors in men, and inhibiting
metastasis is a key event but still a major challenge in prostate cancer treatment. Cancer …

The field of gene therapy still attracts great interest due to its potential therapeutic effect
towards the most deadly diseases, such as cancer. For cancer gene therapy to be feasible …

Gene delivery systems with good biocompatibility and high transfection efficiency play a
major role in the clinical application of gene therapy. It is of great interest to develop a …

Abstract Development of efficient non-viral carriers is one of the major challenges of gene
delivery. In the current study, we designed, synthesized, and evaluated the in vitro gene …

Sequence specific molecules with high folding ability (ie, foldamers) can be used to
precisely control the distribution and projection of side chains in space and have recently …

The nucleus is one of the most important cellular organelles. Chitosan-grafted poly-(N-3-
carbobenzyloxy-lysine)(CCL) decorated with human immunodeficiency virus-1 …

The mechanism that arginine-rich cell penetrating peptides (ARCPPs) use to translocate
lipid membranes is not entirely understood. In the present work, we develop a molecular …

Polyamino acids are versatile macromolecules with potential to be used as bioactive
compounds and drug carriers. Polyaspartic acid (pAsp) and amide conjugate of pAsp with L …