Plasmodium Genomics and Genetics: New Insights into Malaria Pathogenesis, Drug Resistance, Epidemiology, and Evolution

X Su, KD Lane, L Xia, JM Sá… - Clinical microbiology …, 2019 - Am Soc Microbiol
Protozoan Plasmodium parasites are the causative agents of malaria, a deadly disease that
continues to afflict hundreds of millions of people every year. Infections with malaria …

[HTML][HTML] Sticking for a cause: the falciparum malaria parasites cytoadherence paradigm

WC Lee, B Russell, L Rénia - Frontiers in immunology, 2019 - frontiersin.org
After a successful invasion, malaria parasite Plasmodium falciparum extensively remodels
the infected erythrocyte cellular architecture, conferring cytoadhesive properties to the …

Antibodies against Plasmodium falciparum malaria at the molecular level

JP Julien, H Wardemann - Nature Reviews Immunology, 2019 - nature.com
Malaria is a vector-borne disease of global importance, with the vast majority of its life-
threatening cases caused by infection with Plasmodium falciparum parasites. Repeated …

Fenozyme protects the integrity of the blood–brain barrier against experimental cerebral malaria

S Zhao, H Duan, Y Yang, X Yan, K Fan - Nano Letters, 2019 - ACS Publications
Cerebral malaria is a lethal complication of malaria infection characterized by central
nervous system dysfunction and is often not effectively treated by antimalarial combination …

[HTML][HTML] Erythrocyte glycophorins as receptors for Plasmodium merozoites

E Jaskiewicz, M Jodłowska, R Kaczmarek, A Zerka - Parasites & vectors, 2019 - Springer
Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes.
In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in …

Effect of the ABO blood group on susceptibility to severe malaria: a systematic review and meta-analysis

A Degarege, MT Gebrezgi, G Ibanez, M Wahlgren… - Blood reviews, 2019 - Elsevier
Understanding how ABO blood group interacts with Plasmodium falciparum (P. falciparum)
infection may facilitate development of antimalarial treatments and vaccines. This study …

Severe malaria: update on pathophysiology and treatment

JA Brejt, LM Golightly - Current Opinion in Infectious Diseases, 2019 - journals.lww.com
Despite advances in our understanding of malarial pathogenesis much remains unknown.
Antimalarial agents eradicate parasites but no treatments are available to prevent or …

Malaria molecular epidemiology: an evolutionary genetics perspective

AA Escalante, MA Pacheco - Microbiology spectrum, 2019 - Am Soc Microbiol
Malaria is a vector-borne disease that involves multiple parasite species in a variety of
ecological settings. However, the parasite species causing the disease, the prevalence of …

Transmission-blocking vaccines: old friends and new prospects

FK Acquah, J Adjah, KC Williamson… - Infection and …, 2019 - Am Soc Microbiol
In the progression of the life cycle of Plasmodium falciparum, a small proportion of asexual
parasites differentiate into male or female sexual forms called gametocytes. Just like their …

Dissecting the gene expression, localization, membrane topology, and function of the Plasmodium falciparum STEVOR protein family

JS Wichers, JAM Scholz, J Strauss, S Witt, A Lill… - MBio, 2019 - Am Soc Microbiol
During its intraerythrocytic development, the malaria parasite Plasmodium falciparum
exposes variant surface antigens (VSAs) on infected erythrocytes to establish and maintain …