[HTML][HTML] Techniques to study antigen-specific B cell responses

J Boonyaratanakornkit, JJ Taylor - Frontiers in immunology, 2019 - frontiersin.org
Antibodies against foreign antigens are a critical component of the overall immune response
and can facilitate pathogen clearance during a primary infection and also protect against …

B cell tolerance and antibody production to the celiac disease autoantigen transglutaminase 2

MF du Pré, J Blazevski, AE Dewan… - Journal of Experimental …, 2019 - rupress.org
Autoantibodies to transglutaminase 2 (TG2) are hallmarks of celiac disease. To address B
cell tolerance and autoantibody formation to TG2, we generated immunoglobulin knock-in …

Cross-Reactive Antigen Expressed by B6 Splenocytes Drives Receptor Editing and Marginal Zone Differentiation of IgG2a-Reactive AM14 Vκ8 B Cells

K Nündel, P Mande, SL Moses, P Busto… - The Journal of …, 2019 - journals.aai.org
The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2a a/j
with low affinity, and as a result, AM14 B cells only proliferate in response to IgG2a immune …

[HTML][HTML] Cross-reactive antigen expressed by B6 splenocytes drives receptor editing and MZ differentiation of IgG2a-reactive AM14 Vκ8 B cells

K Nündel, P Mande, SL Moses, P Busto… - … (Baltimore, Md.: 1950 …, 2019 - ncbi.nlm.nih.gov
The AM14 BCR, derived from an autoimmune MRL/lpr mouse, binds autologous IgG2a a/j
with low affinity, and as a result AM14 B cells only proliferate in response to IgG2a immune …

[引用][C] Defining B cell tolerance checkpoints and their modulation by immunotherapy

JFK Brooks - 2019 - espace.library.uq.edu.au
B cells that recognise self-antigens are thought to be deleted from the emerging repertoire
and those which escape deletion are instead locked in an anergic state. Autoimmunity …