KDM5B is a master regulator of the H3K4-methylome in stem cells, development and cancer
Epigenetic regulation of chromatin plays a critical role in controlling stem cell function and
tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation …
tumorigenesis. The histone lysine demethylase, KDM5B, which catalyzes the demethylation …
[HTML][HTML] The role of α-ketoglutarate–dependent proteins in pluripotency acquisition and maintenance
KA Tran, CM Dillingham, R Sridharan - Journal of Biological Chemistry, 2019 - ASBMB
α-Ketoglutarate is an important metabolic intermediate that acts as a cofactor for several
chromatin-modifying enzymes, including histone demethylases and the Tet family of …
chromatin-modifying enzymes, including histone demethylases and the Tet family of …
[PDF][PDF] DNA hypermethylation encroachment at CpG island borders in cancer is predisposed by H3K4 monomethylation patterns
Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion
are subject to hypermethylation. Using methylome sequencing we identified CpG islands …
are subject to hypermethylation. Using methylome sequencing we identified CpG islands …
[HTML][HTML] Epigenetic regulation of bone marrow stem cell aging: revealing epigenetic signatures associated with hematopoietic and mesenchymal stem cell aging
D Cakouros, S Gronthos - Aging and disease, 2019 - ncbi.nlm.nih.gov
In this review we explore the importance of epigenetics as a contributing factor for aging
adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult …
adult stem cells. We summarize the latest findings of epigenetic factors deregulated as adult …
[HTML][HTML] NEK2 promotes proliferation, migration and tumor growth of gastric cancer cells via regulating KDM5B/H3K4me3
Y Li, L Chen, L Feng, M Zhu, Q Shen… - American Journal of …, 2019 - ncbi.nlm.nih.gov
The mechanisms of how Never in Mitosis (NIMA) Related Kinase 2 (NEK2) coordinates
altered signaling to malignant gastric cancer (GC) transformation remain unclear …
altered signaling to malignant gastric cancer (GC) transformation remain unclear …
JARID 1B expression and its function in DNA damage repair are tightly regulated by mi RNA s in breast cancer
JARID 1B/KDM 5B histone demethylase's mRNA is markedly overexpressed in breast
cancer tissues and cell lines and the protein has been shown to have a prominent role in …
cancer tissues and cell lines and the protein has been shown to have a prominent role in …
The Set1 complex is dimeric and acts with Jhd2 demethylation to convey symmetrical H3K4 trimethylation
R Choudhury, S Singh, S Arumugam… - Genes & …, 2019 - genesdev.cshlp.org
Epigenetic modifications can maintain or alter the inherent symmetry of the nucleosome.
However, the mechanisms that deposit and/or propagate symmetry or asymmetry are not …
However, the mechanisms that deposit and/or propagate symmetry or asymmetry are not …
[HTML][HTML] Involvement of noncoding RNAs in epigenetic modifications of esophageal cancer
Y Xiao, M Su, W Ou, H Wang, B Tian, J Ma… - Biomedicine & …, 2019 - Elsevier
Esophageal cancer (EC) is a serious digestive malignancy and is a leading cause of cancer-
related mortality. Apart from genetic mutations, many epigenetic alterations including DNA …
related mortality. Apart from genetic mutations, many epigenetic alterations including DNA …
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications
S Tian, J Feng, Y Cao, S Shen, Y Cai… - Life Science …, 2019 - life-science-alliance.org
Metabolic remodelling has emerged as critical for stem cell pluripotency; however, the
underlying mechanisms have yet to be fully elucidated. Here, we found that the glycine …
underlying mechanisms have yet to be fully elucidated. Here, we found that the glycine …
[HTML][HTML] Phosphorylation of the histone demethylase KDM5B and regulation of the phenotype of triple negative breast cancer
Epigenetic modifications are known to play critical roles in the expression of genes related to
differentiation and dedifferentiation. Histone lysine demethylase KDM5B (PLU-1) catalyzes …
differentiation and dedifferentiation. Histone lysine demethylase KDM5B (PLU-1) catalyzes …