Electrochemical oxidation of organic molecules at lower overpotential: Accessing broader functional group compatibility with electron− proton transfer mediators

F Wang, SS Stahl - Accounts of chemical research, 2020 - ACS Publications
Conspectus Electrochemical organic oxidation reactions are highly appealing because
protons are often effective terminal electron acceptors, thereby avoiding undesirable …

Rosuvastatin/ezetimibe: a review in hypercholesterolemia

YN Lamb - American journal of cardiovascular drugs, 2020 - Springer
Rosuvastatin/ezetimibe combines two lipid-lowering agents: rosuvastatin, an HMG-CoA
reductase inhibitor (ie statin) with particularly strong inhibitory effects on hepatic cholesterol …

An overview of rosuvastatin/ezetimibe association for the treatment of hypercholesterolemia and mixed dyslipidemia

L Strilchuk, G Tocci, F Fogacci… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Although statin therapy is a powerful lipid-lowering strategy, only one-fifth of
statin users currently reach their lipid goals. In addition, statin treatment alone has relatively …

[HTML][HTML] Rosuvastatin prevents the exacerbation of atherosclerosis in ligature-induced periodontal disease mouse model

JS Suh, SH Lee, Z Fouladian, JY Lee, T Kim… - Scientific reports, 2020 - nature.com
Periodontitis is a local and systemic inflammatory condition and a risk factor of
atherosclerosis, but no studies investigated the effect of a statin on atherogenesis affected …

Application of the artificial neural network to optimize the formulation of self-nanoemulsifying drug delivery system containing rosuvastatin

GTT Vu, NT Phan, HT Nguyen, HC Nguyen… - Journal of Applied …, 2020 - japsonline.com
The objectives of this study were to optimize the formula of the self-nanoemulsifying drug
delivery system (SNEDDS) containing rosuvastatin and to evaluate its physicochemical …

Assessment of clinical drug‐drug interactions of elagolix, a gonadotropin‐releasing hormone receptor antagonist

AR Polepally, JW Ng, AH Salem… - The Journal of …, 2020 - Wiley Online Library
Elagolix is an oral gonadotropin‐releasing hormone receptor antagonist indicated for the
management of endometriosis‐associated pain and in combination with estradiol …

Impact of SLCO1B1 Genetic Variation on Rosuvastatin Systemic Exposure in Pediatric Hypercholesterolemia

JB Wagner, S Abdel‐Rahman… - Clinical and …, 2020 - Wiley Online Library
This study investigated the impact of SLCO1B1 genotype on rosuvastatin systemic exposure
in hypercholesterolemic children and adolescents. Participants (8–21 years) with at least …

Application of a backpropagation artificial neural network in predicting plasma concentration and pharmacokinetic parameters of oral single‐dose rosuvastatin in …

Y Xu, H Lou, J Chen, B Jiang, D Yang… - … pharmacology in drug …, 2020 - Wiley Online Library
A backpropagation artificial neural network (BPANN) model was established for the
prediction of the plasma concentration and pharmacokinetic parameters of rosuvastatin …

[HTML][HTML] Short-and long-term effects on reproductive parameters of female Wistar rats after exposure to rosuvastatin starting in pre-puberty

JWF Barros, KS Tonon, CS Borges, PV Silva… - Current Research in …, 2020 - Elsevier
Statins are a class of drugs that act lowering lipid levels by inhibiting cholesterol
biosynthesis. Additionally, statins can act by “pleiotropic effects”, related to the inhibition of …

[HTML][HTML] Modeling statin myopathy in a human skeletal muscle microphysiological system

A Ananthakumar, Y Liu, CE Fernandez, GA Truskey… - Plos one, 2020 - journals.plos.org
Statins are used to lower cholesterol and prevent cardiovascular disease. Musculoskeletal
side effects known as statin associated musculoskeletal symptoms (SAMS), are reported in …