[HTML][HTML] Successes and challenges in simulating the folding of large proteins

A Gershenson, S Gosavi, P Faccioli… - Journal of Biological …, 2020 - ASBMB
Computational simulations of protein folding can be used to interpret experimental folding
results, to design new folding experiments, and to test the effects of mutations and small …

Experimentally-driven protein structure modeling

NV Dokholyan - Journal of proteomics, 2020 - Elsevier
Revolutions in natural and exact sciences started at the dawn of last century have led to the
explosion of theoretical, experimental, and computational approaches to determine …

Glassy dynamics and memory effects in an intrinsically disordered protein construct

IL Morgan, R Avinery, G Rahamim, R Beck… - Physical Review Letters, 2020 - APS
Glassy, nonexponential relaxations in globular proteins are typically attributed to
conformational behaviors that are missing from intrinsically disordered proteins. Yet, we …

The complexity of protein structure and the challenges it poses in developing biopharmaceuticals

SA Berkowitz, DJ Houde - Biophysical Characterization of Proteins in …, 2020 - Elsevier
In this chapter the key elements and characteristics of what constitutes the structure of a
protein, along with the associated nomenclature are reviewed. Next, the unique structural …

Protein folding and structure prediction: biological and physical perspectives

MA Chonofsky - 2020 - ora.ox.ac.uk
Protein folding is poorly understood and distinct from protein structure prediction,
encompassing the translation and folding process of proteins in vivo and in vitro. In this …