New insights into malaria pathogenesis
Malaria remains a major public health threat in tropical and subtropical regions across the
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …
world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 …
The impact of delayed treatment of uncomplicated P. falciparum malaria on progression to severe malaria: A systematic review and a pooled multicentre individual …
A Mousa, A Al-Taiar, NM Anstey, C Badaut… - PLoS …, 2020 - journals.plos.org
Background Delay in receiving treatment for uncomplicated malaria (UM) is often reported to
increase the risk of developing severe malaria (SM), but access to treatment remains low in …
increase the risk of developing severe malaria (SM), but access to treatment remains low in …
Molecular switches for regulating the differentiation of inflammatory and IL-10-producing anti-inflammatory T-helper cells
Abstract CD4 T-helper (Th) cells secret a variety of inflammatory cytokines and play critical
roles in host defense against invading foreign pathogens. On the other hand, uncontrolled …
roles in host defense against invading foreign pathogens. On the other hand, uncontrolled …
The regulation of CD4+ T cells during malaria
Malaria is a major global health problem. Despite decades of research, there is still no
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …
effective vaccine to prevent disease in the majority of people living in malaria‐endemic …
Deciphering host immunity to malaria using systems immunology
A century of conceptual and technological advances in infectious disease research has
changed the face of medicine. However, there remains a lack of effective interventions and a …
changed the face of medicine. However, there remains a lack of effective interventions and a …
Using two phases of the CD 4 T cell response to blood‐stage murine malaria to understand regulation of systemic immunity and placental pathology in Plasmodium …
Plasmodium falciparum infection and malaria remain a risk for millions of children and
pregnant women. Here, we seek to integrate knowledge of mouse and human T helper cell …
pregnant women. Here, we seek to integrate knowledge of mouse and human T helper cell …
Comparative analyses revealed reduced spread of COVID-19 in malaria endemic countries
Abstract In late 2019, SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2)
infection started in Hubei province of China and now it has spread like a wildfire in almost all …
infection started in Hubei province of China and now it has spread like a wildfire in almost all …
A population of CD4hiCD38hi T cells correlates with disease severity in patients with acute malaria
Objective CD4+ T cells are critical mediators of immunity to Plasmodium spp. infection, but
their characteristics during malarial episodes and immunopathology in naturally infected …
their characteristics during malarial episodes and immunopathology in naturally infected …
Kynurenine elevation correlates with T regulatory cells increase in acute Plasmodium vivax infection: A pilot study
RO Dos Santos, RM Gonçalves‐Lopes… - Parasite …, 2020 - Wiley Online Library
Background Disease‐tolerance mechanisms limit infection severity by preventing tissue
damage; however, the underlying mechanisms in human malaria are still unclear …
damage; however, the underlying mechanisms in human malaria are still unclear …
Effect of Brugia pahangi co-infection with Plasmodium berghei ANKA in gerbils (Meriones unguiculatus)
OQ Junaid, I Vythilingam, LT Khaw, S Sivanandam… - Parasitology …, 2020 - Springer
Malaria and lymphatic filariasis (LF) are two leading and common mosquito-borne parasitic
diseases worldwide. These two diseases are co-endemic in many tropical and sub-tropical …
diseases worldwide. These two diseases are co-endemic in many tropical and sub-tropical …