Aggressive pituitary tumors (APTs) represent rare pituitary adenomas (PAs) with local
invasion of surrounding tissues, increased risk for multiple recurrence, rapid tumor growth …

Aim To assess objective response after two cycles of temozolomide and topotecan (TOTEM)
in children with refractory or relapsed miscellaneous extracranial solid and central nervous …

Brain tumors are considered as one of the most aggressive and incurable forms of cancer.
The majority of the patients with brain tumors have a median survival rate of 12%. Brain …

Despite advances in the treatment of brain tumors, the prognosis of children with recurrent
malignant brain tumors remains poor. Etoposide (VP-16), an inhibitor of nuclear enzyme …

Central nervous system (CNS) ganglioneuroblastoma is a rare neuroectodermal neoplasm
and little is known about its clinical and biological features. Herein, we report a pediatric …

Introduction: The worldwide incidence of central nervous system (CNS) primary tumors is
increasing. Most of the chemotherapeutic agents used for treating these cancer types induce …

Temozolomide, an alkylating drug first adopted to treat patients with malignant gliomas, is
actually an antineoplastic drug used in various regimens against childhood tumors …

Medulloblastoma (MB) is the first primary central nervous system cancer of infancy. During
the last thirty years, there has been an evolution of its treatment: although chemotherapy and …

Beschreibungen: Medulloblastome (MB) sind die häufigsten bösartigen Hirntumoren im
Kindesalter. Patienten mit hohem Risiko haben eine schlechte Prognose und vor allem jung …

Medulloblastoma (MB), çocukluk çağında görülen en yaygın malign beyin tümörüdür. Bu
tümörlerde tedavi; cerrahiye ek olarak radyoterapi ve kemoterapidir. Ancak uygulanan …