NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Nuclear factor kappa B (NF-κB) signaling is implicated in all major human chronic diseases,
with its role in transcription of hundreds of gene well established in the literature. This has …

Thirty-four years since its discovery, NF-κB remains a transcription factor with great potential
for cancer therapy. However, NF-κB–targeted therapies have yet to find a way to be clinically …

One of the concepts explaining the coincidence of obesity and type 2 diabetes (T2D) is the
metaflammation theory. This chronic, low-grade inflammatory state originating from …

Despite considerable advancements in medicine, the optimal treatment for chronic kidney
disease (CKD), especially diabetic kidney disease (DKD), remains a major challenge. More …

Tumour necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are cytokines that are involved
in the development, proliferation and apoptosis of ovarian follicular cells in domestic …

The noncanonical NF‐κB signaling pathway plays a critical role in a variety of biological
functions including chronic inflammation and tumorigenesis. Activation of noncanonical NF …

Background The nuclear factor kappa B (NF-κB) is composed of a series of transcription
factors, which are involved in the expression of a plethora of target genes, many of these …

High glucose-induced inflammation leads to atherosclerosis, which is considered a major
cause of death in type 1 and type 2 diabetic patients. Nuclear factor-kappa B (NF-κB) plays a …

Crohn's disease (CD) is a chronic inflammatory disease of unknown etiology that covers the
entire digestive tract and occurs with periods of remission and clinical exacerbation. CD is …