Autophagy as a cellular stress response mechanism in the nervous system

N Peker, D Gozuacik - Journal of molecular biology, 2020 - Elsevier
Cells of an organism face with various types of insults during their lifetime. Exposure to
toxins, metabolic problems, ischaemia/reperfusion, physical trauma, genetic diseases …

Underlying mechanisms and potential therapeutic molecular targets in blood-brain barrier disruption after subarachnoid hemorrhage

Y Li, P Wu, JC Bihl, H Shi - Current neuropharmacology, 2020 - ingentaconnect.com
Aneurysmal subarachnoid hemorrhage (aSAH) is a subtype of hemorrhagic stroke with
significant morbidity and mortality. Aneurysmal bleeding causes elevated intracranial …

[HTML][HTML] Advancing human induced pluripotent stem cell‐derived blood‐brain barrier models for studying immune cell interactions

H Nishihara, BD Gastfriend, S Soldati, S Perriot… - The FASEB …, 2020 - ncbi.nlm.nih.gov
Human induced pluripotent stem cell (hiPSC)‐derived blood‐brain barrier (BBB) models
established to date lack expression of key adhesion molecules involved in immune cell …

[HTML][HTML] Neutrophils return to bloodstream through the brain blood vessel after crosstalk with microglia during LPS-induced neuroinflammation

YR Kim, YM Kim, J Lee, J Park, JE Lee… - Frontiers in Cell and …, 2020 - frontiersin.org
The circulatory neutrophil and brain tissue-resident microglia are two important immune
cells involved in neuroinflammation. Since neutrophils that infiltrate through the brain …

[HTML][HTML] Oligodendrocyte precursor cells transplantation protects blood–brain barrier in a mouse model of brain ischemia via Wnt/β-catenin signaling

L Wang, J Geng, M Qu, F Yuan, Y Wang, J Pan… - Cell Death & …, 2020 - nature.com
Blood–brain barrier damage is a critical pathological feature of ischemic stroke.
Oligodendrocyte precursor cells are involved in maintaining blood–brain barrier integrity …

[HTML][HTML] Astrocytic neogenin/netrin-1 pathway promotes blood vessel homeostasis and function in mouse cortex

LL Yao, JX Hu, Q Li, D Lee, X Ren… - The Journal of …, 2020 - Am Soc Clin Investig
Astrocytes have multiple functions in the brain, including affecting blood vessel (BV)
homeostasis and function. However, the underlying mechanisms remain elusive. Here, we …

Serum netrin-1 levels at presentation and delayed neurological sequelae in unintentional carbon monoxide poisoning

K Kokulu, H Mutlu, ET Sert - Clinical Toxicology, 2020 - Taylor & Francis
Objectives: The early identification of patients with a high risk of developing delayed
neurological sequelae (DNS) can improve the quality of care in carbon monoxide (CO) …

Neuroprotective action of teriflunomide in a mouse model of transient middle cerebral artery occlusion

Z Lu, D Zhang, K Cui, X Fu, J Man, H Lu, L Yu, Y Gao… - Neuroscience, 2020 - Elsevier
Teriflunomide has been reported to inhibit microglial activation in experimental models of
traumatic brain injury. However, its roles in ischemic stroke and underlying mechanisms of …

A subtype of cerebrovascular pericytes is associated with blood-brain barrier disruption that develops during normal aging and simian immunodeficiency virus …

DG Bohannon, HR Okhravi, J Kim, MJ Kuroda… - Neurobiology of …, 2020 - Elsevier
Lax phenotypic characterization of these morphologically distinct pericytes has delayed our
understanding of their role in neurological disorders. We herein establish markers which …

Serum netrin-1 concentrations are associated with clinical outcome in acute intracerebral hemorrhage

XH Lou, YY Cai, XQ Yang, HJ Zheng, YJ Yu… - Clinica Chimica …, 2020 - Elsevier
Background Netrin-1 is an axon guidance protein, which can inhibit inflammatory reaction
and stabilize the blood-brain barrier to protect against experimental brain injury. We …