Biomedical scientists use chemistry-driven processes found in nature as an inspiration to
design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue …

Traumatic brain injury leads to cellular damage which in turn results in the rapid release of
damage-associated molecular patterns (DAMPs) that prompt resident cells to release …

Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …

Alzheimer's disease (AD) is the most prevalent form of late-onset dementia. AD affects the
health of millions of people in the United States and worldwide. Currently, there are no …

Rationale: It is known that neuroinflammation plays a critical and detrimental role in the
development of cerebral ischemia/reperfusion (I/R), but the regulation of the cyclic GMP …

Cytosolic double‐stranded DNA (dsDNA) is a danger signal that is tightly monitored and
sensed by nucleic acid‐sensing pattern recognition receptors. We study the inflammatory …

Microglia are the main immune cells in the brain and have roles in brain homeostasis and
neurological diseases. Mechanisms underlying microglia–neuron communication remain …

Objective Inflammasome contributes to ischemic brain injury by inducing pyroptosis and
inflammation. The aim of this study is to unravel the mechanism of long non-coding RNA …

Neurodevelopment is characterized by rapid rates of neural cell proliferation and
differentiation followed by massive cell death in which more than half of all recently …

Intracerebral hemorrhage (ICH) is a subtype of stroke with high mortality and disability but
no specific or effective treatment. In the last two decades, much has been learned about the …