Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. UMs
are usually initiated by a mutation in GNAQ or GNA11, unlike cutaneous melanomas, which …

Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …

PURPOSE To provide recommendations on genetic and tumor testing for women diagnosed
with epithelial ovarian cancer based on available evidence and expert consensus …

Colorectal cancer (CRC) is one of the most common malignant carcinomas in the world, and
metastasis is the main cause of CRC-related death. However, the molecular network …

A crucial feature of gene expression involves RNA processing to produce 3′ ends through
a process termed 3′ end cleavage and polyadenylation (CPA). This ensures the nascent …

Purpose To identify susceptibility genes associated with hereditary predisposition to uveal
melanoma (UM) in patients with no detectable germline BAP1 alterations. Design …

PURPOSE Prior estimates of breast cancer risk in women with Lynch syndrome (LS) range
from population risk to 18-fold increased risk with reported differences by gene. Here, breast …

Purpose: Reducing colorectal cancer incidence and mortality through early detection would
improve efficacy if targeted. We developed a colorectal cancer risk prediction model …

Background Lynch syndrome, the most common colorectal cancer (CRC) syndrome, is
caused by germline mismatch repair (MMR) genes. Precise estimates of age-specific risks …

Background Novel therapeutic agents have improved survival outcomes in patients with
advanced solid tumors. In parallel, the development of predictive biomarkers to identify …