Schwann cells, the most abundant glial cells of the peripheral nervous system, represent the
key players able to supply extracellular microenvironment for axonal regrowth and …

Cognitive impairment is one of the major symptoms in most neurodegenerative disorders
such as Alzheimer's (AD), Parkinson (PD), and Huntington diseases (HD), affecting millions …

Traumatic brain injury remains a growing public health concern and represents the greatest
contributor to death and disability globally among all trauma-related injuries. There are …

Pituitary adenylate cyclase activating polypeptide (PACAP) is a well-conserved
neuropeptide characteristic of vertebrates. This pluripotent hypothalamic neuropeptide …

Introduction: Migraine is a chronic neurovascular disorder characterized by recurrent
headache attacks associated with neurological and autonomic symptoms. The …

The human cornea, a sophisticated example of natural engineering, is composed in the
innermost layer by endothelial cells maintaining stromal hydration and clarity. Different types …

Background Previously reported increases in serum levels of vasodilating neuropeptides
pituitary adenylate cyclase-activating peptide-38 (PACAP38) and vasoactive intestinal …

PACAP was discovered 30 years ago in Dr. Akira Arimura's laboratory. In the past three
decades since then, it has become evident that this peptide plays numerous crucial roles in …

Background Pituitary adenylate cyclase-activating polypeptide (PACAP) occurs as either a
27-or 38-amino acid neuropeptide and belongs to the vasoactive intestinal …

Pituitary adenylate cyclase-activating polypeptide (PACAP) is abundantly expressed in the
hypothalamus and contributes to hypothalamic functions, including appetite regulation …