Atherosclerotic plaques impair vascular function and can lead to arterial obstruction and
tissue ischaemia. Rupture of an atherosclerotic plaque within a coronary artery can result in …

The ease of breeding, low cost of maintenance, and relatively short period for developing
atherosclerosis make rodents ideal for atherosclerosis research. However, none of the …

Vascular disease remains the leading cause of death and disability, the etiology of which
often involves atherosclerosis. The current treatment of atherosclerosis by pharmacotherapy …

Background: Throughout the inflammatory response that accompanies atherosclerosis,
autoreactive CD4+ T-helper cells accumulate in the atherosclerotic plaque. Apolipoprotein …

Rationale: Aging is one of the strongest risk factors for atherosclerosis. Yet whether aging
increases the risk of atherosclerosis independently of chronic hyperlipidemia is not known …

Background and Purpose: Atherosclerosis is an underlying cause of coronary heart disease.
Foam cell, a hallmark of atherosclerosis, is prominently derived from monocyte-differentiated …

Objective: Galectin-3 (formerly known as Mac-2), encoded by the LGALS3 gene, is proposed
to regulate macrophage adhesion, chemotaxis, and apoptosis. We investigated the role of …

Atherosclerosis is a chronic progressive disease, which may result in serious clinical
outcomes, such as acute heart events or stroke with high mortality. At present, the clinical …

Background Aberrant activation of the NLRP 3 (nucleotide‐binding oligomerization domain,
leucine‐rich repeat–containing receptor family pyrin domain‐containing 3) inflammasome is …

Objective: Calcification of atherosclerotic plaque is traditionally associated with increased
cardiovascular event risk; however, recent studies have found increased calcium density to …