DNA methylation at the 5-position of cytosine (5mC) plays vital roles in mammalian
development. DNA methylation is catalyzed by DNA methyltransferases (DNMTs), and the …

Polyomavirus infection is widespread in the human population. This family of viruses
normally maintains latent infection within the host cell but can cause a range of human …

Cellular heterogeneity confounds in situ assays of transcription factor (TF) binding. Single-
cell RNA sequencing (scRNA-seq) deconvolves cell types from gene expression, but no …

Transcriptional memory allows certain genes to respond to previously experienced signals
more robustly. However, whether and how the key proinflammatory cytokine TNF-α mediates …

Epigenetic potential, defined as the capacity for epigenetically-mediated phenotypic
plasticity, may play an important role during range expansions. During range expansions …

(1) Background: The hedgehog (HH) signaling pathway is a key regulator of embryonic
patterning, tissue regeneration, stem cell renewal, and cancer growth. The smoothened …

Dioxins and dioxin-like compounds are persistent organic pollutants (POPs) and
technogenic ecotoxicants, the most dangerous of which is 2, 3, 7, 8-tetrachlorodibenzo-p …

头颈部鳞状细胞癌是一种发生在头颅五官及颈部的恶性肿瘤, 晚期预后较差,
随着诊疗技术的发展, 早期诊断已成为提高预后的关键. DNA 甲基化作为表观遗传学的一种形式 …

In this dissertation, we characterize and analyze CpG islands (CGIs) using Bioinformatics
tools and techniques that lead to an understanding of their biological functions and role in …

The transcription of human genes is therefore concentrated into units and these units appear
to be clustered in groups within nuclear domains in which the transcriptional machinery is …