OBJECTIVE To identify barriers and solutions for the recruitment and retention of older
(aged≥ 65 years) people in clinical trials. DESIGN Systematic literature review. METHODS …

Despite a high incidence of hematologic malignancies in older adults, available data
indicate that there is disproportionately low representation of adults≥ 65 years with …

Can be clinician-or patient-reported, which may lead to discrepancies. Some trusts submit
additional ethnicity subgroups which are not part of the standard 16 þ 1 categories and …

Background Although increasing evidence has suggested that an efficacy‐effectiveness gap
exists between clinical trial (CT) and real‐world evidence (RWE), to the authors' knowledge …

Management of melanoma has been revolutionized by the use of immune checkpoint
inhibitors. Immune system changes associated with aging may affect the efficacy of immune …

Background Older patients with cancer are at increased risk of exposure to polypharmacy
(PP), potential drug interactions (PDIs), and Potentially inappropriate Medications (PIMs) …

Patients with chronic lymphocytic leukemia and unmutated immunoglobulin heavy-chain
variable region gene (IGHV) have inferior survival from time of treatment in clinical studies …

Improvements in breast cancer (BC) mortality rates have not been seen in the older adult
community, and the fact that older adults are more likely to die from their cancer than …

Background Nutritional status can directly affect morbidity and mortality in older adults with
cancer. This study evaluated the association between pretreatment body mass index (BMI) …

Background Age disparities among cancer clinical trial participants are pervasive and
worsening over time. Identification of factors associated with age disparities is critical to …