Biosystems design by machine learning

MJ Volk, I Lourentzou, S Mishra, LT Vo… - ACS synthetic …, 2020 - ACS Publications
Biosystems such as enzymes, pathways, and whole cells have been increasingly explored
for biotechnological applications. However, the intricate connectivity and resulting …

SEVA 3.0: an update of the Standard European Vector Architecture for enabling portability of genetic constructs among diverse bacterial hosts

E Martínez-García, A Goni-Moreno… - Nucleic acids …, 2020 - academic.oup.com
Abstract The Standard European Vector Architecture 3.0 database (SEVA-DB 3.0,
http://seva. cnb. csic. es) is the update of the platform launched in 2013 both as a web-based …

The synthetic biology open language (SBOL) version 3: simplified data exchange for bioengineering

JA McLaughlin, J Beal, G Mısırlı, R Grünberg… - … in Bioengineering and …, 2020 - frontiersin.org
The Synthetic Biology Open Language (SBOL) is a community-developed data standard that
allows knowledge about biological designs to be captured using a machine-tractable …

Organizing genome engineering for the gigabase scale

BA Bartley, J Beal, JR Karr, EA Strychalski - Nature communications, 2020 - nature.com
Genome-scale engineering holds great potential to impact science, industry, medicine, and
society, and recent improvements in DNA synthesis have enabled the manipulation of …

The long journey towards standards for engineering biosystems: Are the Molecular Biology and the Biotech communities ready to standardise?

J Beal, A Goñi‐Moreno, C Myers, A Hecht… - EMBO …, 2020 - embopress.org
Standards are the basis of technology: they allow rigorous description and exact
measurement of properties, reliable reproducibility and a common “language” that enables …

SEVA 3.1: enabling interoperability of DNA assembly among the SEVA, BioBricks and Type IIS restriction enzyme standards

SG Damalas, C Batianis… - Microbial …, 2020 - Wiley Online Library
Robust synthetic biology applications rely heavily on the design and assembly of DNA parts
with specific functionalities based on engineering principles. However, the assembly …

Genetic circuit dynamics: hazard and glitch analysis

P Fontanarrosa, H Doosthosseini… - ACS synthetic …, 2020 - ACS Publications
Multiple input changes can cause unwanted switching variations, or glitches, in the output of
genetic combinational circuits. These glitches can have drastic effects if the output of the …

The first 10 years of the international coordination network for standards in systems and synthetic biology (COMBINE)

D Waltemath, M Golebiewski, ML Blinov… - Journal of integrative …, 2020 - degruyter.com
This paper presents a report on outcomes of the 10th Computational Modeling in Biology
Network (COMBINE) meeting that was held in Heidelberg, Germany, in July of 2019. The …

Multiplexing cell‐cell communication

JT Sexton, JJ Tabor - Molecular systems biology, 2020 - embopress.org
The engineering of advanced multicellular behaviors, such as the programmed growth of
biofilms or tissues, requires cells to communicate multiple aspects of physiological …

Evaluation of industry 4.0 data formats for digital twin of optical components

A Schmetz, TH Lee, M Hoeren, M Berger… - International Journal of …, 2020 - Springer
A wide range of software and hardware components are present in today's production
systems and plants using a variety of interfaces and data formats for information exchange …