The mitochondrion is an organelle that plays a vital role in the regulation of hepatic cellular
redox, lipid metabolism, and cell death. Mitochondrial dysfunction is associated with both …

Autophagy is a highly conserved catabolic process that degrades cytosolic proteins and
organelles via formation of autophagosomes that fuse with lysosomes to form …

Background & Aims Autophagy plays a crucial role in hepatic homeostasis and its
deregulation has been associated with chronic liver disease. However, the effect of …

Background & Aims Hepatomegaly can be triggered by insulin and insulin-unrelated
etiologies. Insulin acts via AKT, but how other challenges cause hepatomegaly is unknown …

Fibrosis occurs in most human organs including the liver, lung, heart and kidney, and is
crucial for the progression of most chronic diseases. As an indispensable catabolic process …

Toxicity from drugs has become an important cause of acute liver failure. Acetaminophen, a
commonly used analgesic, can cause severe acute liver injury that can worsen into acute …

Background and aims Autophagy is a critical process in cell survival and the maintenance of
homeostasis. However, the implementation of therapeutic approaches based on autophagy …

Autophagy is an intracellular lysosomal degradative pathway important for tumor
surveillance. Autophagy deficiency can lead to tumorigenesis. Autophagy is also known to …

The mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of
metabolism that integrates environmental inputs, including nutrients, growth factors, and …

Although the role of autophagy has been implicated in several forms of chronic hepatitis, it is
still not fully understood. Active autophagy eliminates damaged molecules and organelles …