Ca 2+ is an essential signal for pancreatic β-cell function. Ca 2+ plays critical roles in
numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic …

Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-
economic burden. Calcium (Ca2+) dysregulation is key hallmark of the failing myocardium …

Much remains to be discovered about the intersection of tissue-specific transcription control
and the epigenetics of skeletal muscle (SkM), a very complex and dynamic organ. From four …

Rationale: Trimeric intracellular cation (TRIC)-A and B are distributed to endoplasmic
reticulum/sarcoplasmic reticulum intracellular Ca2+ stores. The crystal structure of TRIC has …

Sarcopenia, the loss of muscle mass and strength associated with age, has been linked to
impairment of the cytosolic Ca2+ peak that triggers muscle contraction, but mechanistic …

Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release
from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals. Here, we …

A central point in heart research is to understand the mechanisms behind Ca2+ handling
and to find alternatives to correct defective Ca2+ cycling associated with heart failure and …

Changes in intracellular calcium levels in the sinus node modulate cardiac pacemaking (the
calcium clock). Trimeric intracellular cation (TRIC) channels are counterion channels on the …

Para empezar una tesis hace falta valentía, vocación y motivación, pero para acabarla hace
falta perseverancia, constancia, disciplina, fuerza y paciencia. Por tanto, en primer lugar …

Abstract Defective ER/SR-cytosol Ca 2+ cycling is associated with increased ER stress,
pathological heart conditions and muscular defects. Within the SR, ryanodine receptor 2 …