Zebrafish as a model of neurodevelopmental disorders

MS De Abreu, R Genario, ACVV Giacomini, KA Demin… - Neuroscience, 2020 - Elsevier
Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development
are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are …

Impact of ketamine on the behavior and immune system of adult medaka (Oryzias latipes) at environmentally relevant concentrations and eco-risk assessment in …

Z Wang, Z Xu, Y Wu, Z Zhang, X Li - Journal of hazardous materials, 2020 - Elsevier
This work for the first time investigated the bioconcentration factor (BCF), toxicity, and eco-
risk of KET using adult medaka fish (Oryzias latipes) as model organism after exposure at …

N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish

Q Gu, J Rodgers, B Robinson, J Kanungo - Food and Chemical Toxicology, 2020 - Elsevier
There is a strong association between calcium channel blockers (CCBs) and heart failure.
CCB toxicity is very common due to overdose and underlying medical conditions. CCBs also …

Acetyl-l-carnitine does not prevent neurodegeneration in a rodent model of prolonged neonatal anesthesia

JL Walters, JJ Chelonis, CM Fogle, SA Ferguson… - Neurotoxicology and …, 2020 - Elsevier
Many studies have shown that prolonged or repeated use of general anesthesia early in life
can cause an increase in neurodegeneration and lasting changes in behavior. While short …

Nifedipine toxicity is exacerbated by acetyl l‐carnitine but alleviated by low‐dose ketamine in zebrafish in vivo

BL Robinson, Q Gu, V Tryndyak, SF Ali… - Journal of Applied …, 2020 - Wiley Online Library
Calcium channel blocker (CCB) poisoning is a common and sometimes life‐threatening
emergency. Our previous studies have shown that acetyl l‐carnitine (ALCAR) prevents …