Insulin-like growth factors (IGFs) play important roles in mammalian growth, development,
aging, and diseases. Aberrant IGFs signaling may lead to malignant transformation and …

Ewing sarcoma (ES) is a rare, highly aggressive, bone, or soft tissue-associated tumor.
Although this sarcoma often responds well to initial chemotherapy, 40% of the patients …

Phenotypic heterogeneity in cancer is often caused by different patterns of genetic
alterations. Understanding such phenotype-genotype relationships is fundamental for the …

Nonketotic-hypoinsulinemic hypoglycemia (NkHH) is a very rare problem charcterized by
increase in glucose consumption without hyperinsulinism. This disorder has mainly been …

We followed a comprehensive computational strategy to understand and eventually predict
the structure-activity relationship of thirty-three 1, 3-disubstituted imidazole [1, 5-α] pyrazine …