Isolated autoimmune adrenocorticotropic hormone deficiency: from a rare disease to the dominant cause of adrenal insufficiency related to check point inhibitors
Objective Immune checkpoint inhibitors have introduced a new and heterogeneous class of
immune-related adverse effects, with the endocrine system being a predominant target for …
immune-related adverse effects, with the endocrine system being a predominant target for …
[HTML][HTML] Biointerface engineering nanoplatforms for cancer-targeted drug delivery
H Zhang, S Dong, Z Li, X Feng, W Xu… - Asian Journal of …, 2020 - Elsevier
Over the past decade, nanoparticle-based therapeutic modalities have become promising
strategies in cancer therapy. Selective delivery of anticancer drugs to the lesion sites is …
strategies in cancer therapy. Selective delivery of anticancer drugs to the lesion sites is …
[HTML][HTML] Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway
X Deng, J Liu, L Liu, X Sun, J Huang… - International Journal of …, 2020 - ncbi.nlm.nih.gov
Baicalein (BA), a natural compound extracted from Scutellaria baicalensis Georgi, has been
reported to exert antitumor effect in various cancers. However, the underlying mechanisms …
reported to exert antitumor effect in various cancers. However, the underlying mechanisms …
Overt thyroid dysfunction and anti-thyroid antibodies predict response to anti-PD-1 immunotherapy in cancer patients
EA Basak, JWM van der Meer, DP Hurkmans… - Thyroid, 2020 - liebertpub.com
Background: Thyroid dysfunction is among the most common adverse effects during anti-
programmed cell death 1 (PD-1) immunotherapy, and alongside correlations with elevated …
programmed cell death 1 (PD-1) immunotherapy, and alongside correlations with elevated …
Evolving insights into the mechanisms of toxicity associated with immune checkpoint inhibitor therapy
Immune checkpoint inhibitors have emerged as a revolutionary treatment option for patients
with various types of malignancy. Although these agents afford a significant improvement in …
with various types of malignancy. Although these agents afford a significant improvement in …
Hypophysitis (including IgG4 and immunotherapy)
Hypophysitis is characterized by inflammation of the pituitary gland that can be primary (PH)
or secondary (SH) to other diseases or following drug administration. It may also be …
or secondary (SH) to other diseases or following drug administration. It may also be …
Breast cancer during pregnancy: a marked propensity to triple-negative phenotype
Breast and cervical cancers comprise 50% of all cancers during pregnancy. In particular,
gestational breast cancer is considered one of the most aggressive types of cancers, which …
gestational breast cancer is considered one of the most aggressive types of cancers, which …
Endocrinopathies associated with immune checkpoint inhibitor cancer treatment: a review
N Okura, M Asano, J Uchino, Y Morimoto… - Journal of Clinical …, 2020 - mdpi.com
Treatment with immune checkpoint inhibitors has shown efficacy against a variety of cancer
types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and …
types. The effects of nivolumab and pembrolizumab on lung cancer have been reported, and …
Check point inhibitors and autoimmunity: Why endocrinopathies and who is prone to?
R Percik, Y Shoenfeld - Best Practice & Research Clinical Endocrinology & …, 2020 - Elsevier
Immunotherapy has transformed the treatment of cancer by restoring the power of the
immune system against tumor cells. Disruption of the innate immune inhibition has …
immune system against tumor cells. Disruption of the innate immune inhibition has …
Immune checkpoint inhibitors and endocrine side effects, a narrative review
L Agrawal, A Bacal, S Jain, V Singh… - Postgraduate …, 2020 - Taylor & Francis
Immune checkpoint inhibitors (ICPIs) are novel drugs in the field of oncology however carry
the risk of immune-related dermatologic, gastrointestinal, and endocrine side effects which …
the risk of immune-related dermatologic, gastrointestinal, and endocrine side effects which …