The airway epithelium represents a physical barrier to the external environment acting as
the first line of defence against potentially harmful environmental stimuli including microbes …

The upper airways play a critical role in the respiratory system by conditioning and clearing
contaminants from the inspired airstream before it accesses the lower respiratory system. 1 …

Cigarette smoke first interacts with the lung through the cellularly diverse airway epithelium
and goes on to drive development of most chronic lung diseases. Here, through single cell …

Our understanding of dynamic interactions between airway basal stem cells (ABSCs) and
their signaling niches in homeostasis, injury, and aging remains elusive. Using transgenic …

Submucosal glands (SMGs) are a prominent structure that lines human cartilaginous
airways. Although it has been assumed that SMGs contribute to respiratory defense, that …

Animal models of cystic fibrosis (CF) are essential for investigating disease mechanisms and
trialing potential therapeutics. This study generated two CF rat models using clustered …

In response to respiratory insults, airway submucosal glands secrete copious mucus strands
to increase mucociliary clearance and protect the lung. However, in cystic fibrosis …

After more than two decades since clinical trials tested the first use of recombinant adeno-
associated virus (rAAV) to treat cystic fibrosis (CF) lung disease, gene therapy for this …

The respiratory epithelium can be affected by many diseases that could be treated using
aerosol gene therapy. Among these, cystic fibrosis (CF) is a lethal inherited disease …

Cystic Fibrosis (CF) is a chronic autosomal recessive disease caused by defects in the cystic
fibrosis transmembrane conductance regulator gene (CFTR). Cystic Fibrosis affects multiple …