A roadmap to integrate astrocytes into Systems Neuroscience

KV Kastanenka, R Moreno‐Bote, M De Pittà, G Perea… - Glia, 2020 - Wiley Online Library
Abstract Systems neuroscience is still mainly a neuronal field, despite the plethora of
evidence supporting the fact that astrocytes modulate local neural circuits, networks, and …

Rodent medial and lateral orbitofrontal cortices represent unique components of cognitive maps of task space

LA Bradfield, G Hart - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
The orbitofrontal cortex (OFC) has been proposed to function as a cognitive map of task
space: a mental model of the steps involved in a task. This idea has proven popular because …

Transient and persistent representations of odor value in prefrontal cortex

PY Wang, C Boboila, M Chin, A Higashi-Howard… - Neuron, 2020 - cell.com
The representation of odor in olfactory cortex (piriform) is distributive and unstructured and
can only be afforded behavioral significance upon learning. We performed 2-photon …

[HTML][HTML] Context-dependent decision making in a premotor circuit

Z Wu, A Litwin-Kumar, P Shamash, A Taylor, R Axel… - Neuron, 2020 - cell.com
Cognitive capacities afford contingent associations between sensory information and
behavioral responses. We studied this problem using an olfactory delayed match to sample …

Dissociable and paradoxical roles of rat medial and lateral orbitofrontal cortex in visual serial reversal learning

ME Hervig, L Fiddian, L Piilgaard, T Božič… - Cerebral …, 2020 - academic.oup.com
Much evidence suggests that reversal learning is mediated by cortico-striatal circuitries with
the orbitofrontal cortex (OFC) playing a prominent role. The OFC is a functionally …

Responding to preconditioned cues is devaluation sensitive and requires orbitofrontal cortex during cue-cue learning

EE Hart, MJ Sharpe, MPH Gardner, G Schoenbaum - elife, 2020 - elifesciences.org
The orbitofrontal cortex (OFC) is necessary for inferring value in tests of model-based
reasoning, including in sensory preconditioning. This involvement could be accounted for by …

Processing in lateral orbitofrontal cortex is required to estimate subjective preference during initial, but not established, economic choice

MPH Gardner, D Sanchez, JC Conroy, AM Wikenheiser… - Neuron, 2020 - cell.com
The orbitofrontal cortex (OFC) is proposed to be critical to economic decision making. Yet
one can inactivate OFC without affecting well-practiced choices. One possible explanation of …

Prefrontal regulation of behavioural control: evidence from learning theory and translational approaches in rodents

KM Turner, SL Parkes - Neuroscience & Biobehavioral Reviews, 2020 - Elsevier
Everyday activities require adaptive decision-making and control over our actions to achieve
our goals. Sub-regions within the cortex are widely reported to regulate these choices. Here …

Multiple factors affect discrimination learning performance, but not between-individual variation, in wild mixed-species flocks of birds

MS Reichert, SJ Crofts… - Royal Society …, 2020 - royalsocietypublishing.org
Cognition arguably drives most behaviours in animals, but whether and why individuals in
the wild vary consistently in their cognitive performance is scarcely known, especially under …

Confidence in Decision-Making during Probabilistic Tactile Learning Related to Distinct Thalamo–Prefrontal Pathways

BA Wang, B Pleger - Cerebral cortex, 2020 - academic.oup.com
The flexibility in adjusting the decision strategy from trial to trial is a prerequisite for learning
in a probabilistic environment. Corresponding neural underpinnings remain largely …