A fundamental goal in cancer research is to understand the mechanisms of cell
transformation. This is key to developing more efficient cancer detection methods and …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

A high tumour mutational burden (hypermutation) is observed in some gliomas,,,–; however,
the mechanisms by which hypermutation develops and whether it predicts the response to …

Given that the PI3K/AKT pathway has manifested its compelling influence on multiple
cellular process, we further review the roles of hyperactivation of PI3K/AKT pathway in …

Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …

There has been huge progress in the discovery of targeted cancer therapies in recent years.
However, even for the most successful and impactful cancer drugs which have been …

With the advent of effective tools to study lipids, including mass spectrometry-based
lipidomics, lipids are emerging as central players in cancer biology. Lipids function as …

Glioblastomas exhibit vast inter-and intra-tumoral heterogeneity, complicating the
development of effective therapeutic strategies. Current in vitro models are limited in …

Translation of survival benefits observed in glioblastoma clinical trials to populations and to
longer-term survival remains uncertain. We aimed to assess if≥ 2-year survival has …

Although radiation is widely used to treat cancers, resistance mechanisms often develop
and involve activation of DNA repair and inhibition of apoptosis. Therefore, compounds that …