Bloodstream infection (BSI) is defined by positive blood cultures in a patient with systemic
signs of infection and may be either secondary to a documented source or primary—that is …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

Summary Background Carbapenem-resistant Enterobacterales (CRE) are a global threat.
We aimed to describe the clinical and molecular characteristics of Centers for Disease …

Background Bloodstream infections comprise a wide variety of pathogens and clinical
syndromes with considerable overlap with similar syndromes of non-bacteraemic infections …

Abstract Objectives Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP)
have been increasingly reported in China. Here, a multicentre, longitudinal surveillance …

Despite being members of gut microbiota, Enterobacteriaceae are associated with many
severe infections such as bloodstream infections. The β-lactam drugs have been the …

Background Antimicrobial de-escalation (ADE) is a strategy of antimicrobial stewardship,
aiming at preventing the emergence of antimicrobial resistance (AMR) by decreasing the …

The management of carbapenem-resistant infections is often based on polymyxins,
tigecycline, aminoglycosides and their combinations. However, in a recent systematic …

Acute leukemias are a group of aggressive malignant diseases associated with a high
degree of morbidity and mortality. An important cause of both the latter is infectious …

Infections due to carbapenem-resistant Enterobacteriaceae (CRE) are increasingly
prevalent in children and are associated with poor clinical outcomes. Optimal treatment …