The role of microRNAs, long non-coding RNAs, and circular RNAs in cervical cancer
Prolonged infection of uterine cervix epithelium with human papillomavirus (HPV) and
constitutive expression of viral oncogenes have been recognized as the main cause of the …
constitutive expression of viral oncogenes have been recognized as the main cause of the …
Association of oral dysbiosis with oral cancer development
Oral squamous cell carcinoma (OSCC) is the leading cause of mortality for oral cancer.
Numerous risk factors mainly related to unhealthy habits and responsible for chronic …
Numerous risk factors mainly related to unhealthy habits and responsible for chronic …
HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers
The dominant paradigm for HPV carcinogenesis includes integration into the host genome
followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic …
followed by expression of E6 and E7 (E6/E7). We explored an alternative carcinogenic …
Recent insight into the role of FBXW7 as a tumor suppressor
K Yumimoto, KI Nakayama - Seminars in cancer biology, 2020 - Elsevier
FBXW7 (also known as Fbw7, Sel10, hCDC4, or hAgo) is a tumor suppressor and the most
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
frequently mutated member of the F-box protein family in human cancers. FBXW7 functions …
Cervical adenocarcinoma: integration of HPV status, pattern of invasion, morphology and molecular markers into classification
KJ Park - Histopathology, 2020 - Wiley Online Library
Cervical adenocarcinoma is a heterogenous group of tumours with various aetiologies,
molecular drivers, morphologies, response to treatment and prognosis. It has become …
molecular drivers, morphologies, response to treatment and prognosis. It has become …
FBW7 mediates senescence and pulmonary fibrosis through telomere uncapping
L Wang, R Chen, G Li, Z Wang, J Liu, Y Liang, JP Liu - Cell Metabolism, 2020 - cell.com
Tissue stem cells undergo premature senescence under stress, promoting age-related
diseases; however, the associated mechanisms remain unclear. Here, we report that in …
diseases; however, the associated mechanisms remain unclear. Here, we report that in …
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate
Gallbladder cancer (GBC) is an aggressive gastrointestinal malignancy with no approved
targeted therapy. Here, we analyze exomes (n= 160), transcriptomes (n= 115), and low pass …
targeted therapy. Here, we analyze exomes (n= 160), transcriptomes (n= 115), and low pass …
Analysis of Ugandan cervical carcinomas identifies human papillomavirus clade–specific epigenome and transcriptome landscapes
Cervical cancer is the most common cancer affecting sub-Saharan African women and is
prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer …
prevalent among HIV-positive (HIV+) individuals. No comprehensive profiling of cancer …
[HTML][HTML] HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical …
C Cao, P Hong, X Huang, D Lin, G Cao, L Wang… - Journal of genetics and …, 2020 - Elsevier
Integration of human papillomavirus (HPV) DNA into the human genome is a reputed key
driver of cervical cancer. However, the effects of HPV integration on chromatin structural …
driver of cervical cancer. However, the effects of HPV integration on chromatin structural …
[HTML][HTML] Neratinib in patients with HER2-mutant, metastatic cervical cancer: Findings from the phase 2 SUMMIT basket trial
A Oaknin, CF Friedman, LD Roman, A D'Souza… - Gynecologic …, 2020 - Elsevier
Objective Somatic HER2 mutations occur in~ 5% of cervical cancers and are considered
oncogenic and associated with poor prognosis. Neratinib, an irreversible pan-HER tyrosine …
oncogenic and associated with poor prognosis. Neratinib, an irreversible pan-HER tyrosine …