A critical review of bottom-up proteomics: the good, the bad, and the future of this field

EJ Dupree, M Jayathirtha, H Yorkey, M Mihasan… - Proteomes, 2020 - mdpi.com
Proteomics is the field of study that includes the analysis of proteins, from either a basic
science prospective or a clinical one. Proteins can be investigated for their abundance …

Recent advancements in polyethyleneimine-based materials and their biomedical, biotechnology, and biomaterial applications

Z Chen, Z Lv, Y Sun, Z Chi, G Qing - Journal of Materials Chemistry B, 2020 - pubs.rsc.org
Cationic polymers, known for their highly positive charges, have historically dominated the
materials used in bioengineering. However, the demand for intelligent systems with high …

Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection

CB Messner, V Demichev, D Wendisch, L Michalick… - Cell systems, 2020 - cell.com
The COVID-19 pandemic is an unprecedented global challenge, and point-of-care
diagnostic classifiers are urgently required. Here, we present a platform for ultra-high …

Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

JE Blume, WC Manning, G Troiano, D Hornburg… - Nature …, 2020 - nature.com
Large-scale, unbiased proteomics studies are constrained by the complexity of the plasma
proteome. Here we report a highly parallel protein quantitation platform integrating …

Facile synthesis of novel reduced graphene oxide@ polystyrene nanospheres for sensitive label-free electrochemical immunoassay

Q Lan, H Shen, J Li, C Ren, X Hu, Z Yang - Chemical Communications, 2020 - pubs.rsc.org
Herein, we report the synthesis of novel nanosized reduced graphene oxide@ polystyrene
nanospheres (rGO@ PS NSs) through an electrostatic interaction method, and further their …

Conjugating immunoassays to mass spectrometry: Solutions to contemporary challenges in clinical diagnostics

KG Stevens, TL Pukala - TrAC Trends in Analytical Chemistry, 2020 - Elsevier
Developments in immunoassays and mass spectrometry have independently influenced
diagnostic technology. However, both techniques possess unique strengths and limitations …

Rapid prostate cancer noninvasive biomarker screening using segmented flow mass spectrometry-based untargeted metabolomics

FG Pinto, I Mahmud, TA Harmon… - Journal of proteome …, 2020 - ACS Publications
Spectrometric methods with rapid biomarker detection capacity through untargeted
metabolomics are becoming essential in the clinical cancer research. Liquid …

Analytical chemistry in the 21st century: Challenges, solutions, and future perspectives of complex matrices quantitative analyses in biological/clinical field

GM Merone, A Tartaglia, M Locatelli, C D'Ovidio… - Analytica, 2020 - mdpi.com
Nowadays, the challenges in analytical chemistry, and mostly in quantitative analysis,
include the development and validation of new materials, strategies and procedures to meet …

Microwave-assisted preparation of ZnFe2O4-Ag/rGO nanocomposites for amplification signal detection of alpha-fetoprotein

M Wu, Y Yang, K Cao, C Zhao, X Qiao, C Hong - Bioelectrochemistry, 2020 - Elsevier
In this study, a novel signal-amplified immunosensor was designed by using a microwave-
assisted self-assembly method to synthesize ZnFe 2 O 4-Ag/rGO nanocomposites. The …

Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics

CB Messner, V Demichev, D Wendisch, L Michalick… - MedRxiv, 2020 - medrxiv.org
The COVID-19 pandemic is an unprecedented global challenge. Highly variable in its
presentation, spread and clinical outcome, novel point-of-care diagnostic classifiers are …