[HTML][HTML] The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology

A Rutsch, JB Kantsjö, F Ronchi - Frontiers in immunology, 2020 - frontiersin.org
The human microbiota has a fundamental role in host physiology and pathology. Gut
microbial alteration, also known as dysbiosis, is a condition associated not only with …

[HTML][HTML] The bidirectional relationship of depression and inflammation: double trouble

E Beurel, M Toups, CB Nemeroff - Neuron, 2020 - cell.com
Depression represents the number one cause of disability worldwide and is often fatal.
Inflammatory processes have been implicated in the pathophysiology of depression. It is …

[HTML][HTML] Altered composition of gut microbiota in depression: a systematic review

ZA Barandouzi, AR Starkweather… - Frontiers in …, 2020 - frontiersin.org
Cumulative evidence shows a linkage between gut microbiota pattern and depression
through the brain-gut microbiome axis. The aim of this systematic review was to identify the …

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

T Ali, SU Rahman, Q Hao, W Li, Z Liu… - Journal of pineal …, 2020 - Wiley Online Library
Major depressive disorder (MDD) is a life‐threatening illness characterized by mood
changes and high rates of suicide. Although the role of neuroinflammation in MMD has been …

The “entourage effect”: terpenes coupled with cannabinoids for the treatment of mood disorders and anxiety disorders

SG Ferber, D Namdar, D Hen-Shoval… - Current …, 2020 - ingentaconnect.com
Mood disorders are the most prevalent mental conditions encountered in psychiatric
practice. Numerous patients suffering from mood disorders present with treatment-resistant …

[HTML][HTML] Gut microbiome composition and diversity are related to human personality traits

KVA Johnson - Human Microbiome Journal, 2020 - Elsevier
The gut microbiome has a measurable impact on the brain, influencing stress, anxiety,
depressive symptoms and social behaviour. This microbiome–gut–brain axis may be …

[HTML][HTML] The microbiota-immune axis as a central mediator of gut-brain communication

TC Fung - Neurobiology of disease, 2020 - Elsevier
Intestinal inflammatory disorders are associated with neurophysiological and behavioral
symptoms. Conversely, many disorders of the central nervous system (CNS) are …

Reductions in anti-inflammatory gut bacteria are associated with depression in a sample of young adults

RT Liu, AD Rowan-Nash, AE Sheehan… - Brain, behavior, and …, 2020 - Elsevier
We assessed the gut microbiota of 90 American young adults, comparing 43 participants
with major depressive disorder (MDD) and 47 healthy controls, and found that the MDD …

[HTML][HTML] Molecular mechanisms of the rapid-acting and long-lasting antidepressant actions of (R)-ketamine

K Hashimoto - Biochemical Pharmacology, 2020 - Elsevier
Ketamine, an anesthetic developed in the early 1960s, is also a popular abused drug
among young people at dance parties and raves and among spiritual seekers, because it …

[HTML][HTML] Ingestion of Lactobacillus intestinalis and Lactobacillus reuteri causes depression- and anhedonia-like phenotypes in antibiotic-treated mice via the vagus …

S Wang, T Ishima, J Zhang, Y Qu, L Chang… - Journal of …, 2020 - Springer
Background The brain–gut–microbiota axis plays a role in the pathogenesis of stress-related
disorders such as depression. In this study, we examined the effects of fecal microbiota …