[PDF][PDF] Epidemiology of glaucoma: the past, present, and predictions for the future

K Allison, D Patel, O Alabi - Cureus, 2020 - cureus.com
Glaucoma is a multifactorial optic degenerative neuropathy characterized by the loss of
retinal ganglion cells. It is a combination of vascular, genetic, anatomical, and immune …

[HTML][HTML] The diagnosis and treatment of glaucoma

AK Schuster, C Erb, EM Hoffmann… - Deutsches Ärzteblatt …, 2020 - ncbi.nlm.nih.gov
Background Glaucoma is a group of chronically progressive disorders of the optic nerve. In
this article, we present the epidemiology of and risk factors for glaucoma, as well as the …

Accurate prediction of glaucoma from colour fundus images with a convolutional neural network that relies on active and transfer learning

R Hemelings, B Elen, J Barbosa-Breda… - Acta …, 2020 - Wiley Online Library
Purpose To assess the use of deep learning (DL) for computer‐assisted glaucoma
identification, and the impact of training using images selected by an active learning …

[HTML][HTML] Molecular genetics of glaucoma: Subtype and ethnicity considerations

R Zukerman, A Harris, A Verticchio Vercellin, B Siesky… - Genes, 2020 - mdpi.com
Glaucoma, the world's leading cause of irreversible blindness, is a complex disease, with
differential presentation as well as ethnic and geographic disparities. The multifactorial …

[HTML][HTML] ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

RB Kasetti, PD Patel, P Maddineni, S Patil… - Nature …, 2020 - nature.com
The underlying pathological mechanisms of glaucomatous trabecular meshwork (TM)
damage and elevation of intraocular pressure (IOP) are poorly understood. Here, we report …

[HTML][HTML] CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of …

P Maddineni, RB Kasetti, PD Patel, JC Millar… - Molecular …, 2020 - Springer
Background Glaucoma is a leading neurodegenerative disease affecting over 70 million
individuals worldwide. Early pathological events of axonal degeneration and retinopathy in …

A review of systemic medications that may modulate the risk of glaucoma

A Wu, AP Khawaja, LR Pasquale, JD Stein - Eye, 2020 - nature.com
With increasing longevity, patients are developing more and more chronic diseases that
require treatment with medications. Yet, it is not fully understood the extent by which these …

Heavy metal toxicity and the aetiology of glaucoma

S Vennam, S Georgoulas, A Khawaja, S Chua… - Eye, 2020 - nature.com
Despite recent advances, our understanding of the aetiological mechanisms underlying
glaucoma remains incomplete. Heavy metals toxicity has been linked to the development of …

Current and new pharmacotherapeutic approaches for glaucoma

WS Shalaby, V Shankar, R Razeghinejad… - Expert Opinion on …, 2020 - Taylor & Francis
Introduction Glaucoma is the leading cause of irreversible blindness worldwide. Medical
therapy is the main line of treatment of open-angle glaucoma (OAG) and ocular …

Connective tissue remodeling in myopia and its potential role in increasing risk of glaucoma

R Grytz, H Yang, Y Hua, BC Samuels… - Current opinion in …, 2020 - Elsevier
Myopia and glaucoma are both increasing in prevalence and are linked by an unknown
mechanism as many epidemiologic studies have identified moderate to high myopia as an …