Iron accumulation is a recurring pathological phenomenon in many neurological diseases
including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and …

Iron is an essential micronutrient and a critical cofactor for proteins involved in fundamental
processes such as oxygen transport, energy production and DNA synthesis. However, iron …

Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …

Accumulating evidence highlights links between iron regulation and respiratory disease.
Here, we assessed the relationship between iron levels and regulatory responses in clinical …

Hereditary hemochromatosis (HH), an iron-overload disease, is a prevalent genetic
disorder. As excess iron causes a multitude of metabolic disturbances, we postulated that …

Iron is an essential element for Mycobacterium tuberculosis; it has at least 40 enzymes that
require iron as a cofactor. Accessibility of iron at the phagosomal surface inside macrophage …

Iron overload is an undesired effect of frequent blood transfusions or genetic diseases.
Myelodysplastic syndrome (MDS) patients become transfusion dependent, but due to the …

Hepatocellular carcinoma (HCC) is a major and increasing cause of clinical and economic
burden worldwide. Now that there are effective therapies to control or eradicate viral …

Patients with thalassemia, myelodysplastic syndromes, sickle cell disease and other
acquired anemia require life sustaining and often repeated red blood cell transfusions …

Disorders of hemoglobin, such as sickle cell anemia and thalassemia, are an increasing
global health concern for which patients must regularly receive blood transfusions …