A systematic review of the role of eculizumab in systemic lupus erythematosus-associated thrombotic microangiopathy

RD Wright, F Bannerman, MW Beresford, L Oni - BMC nephrology, 2020 - Springer
Background Lupus nephritis (LN) is a severe consequence of systemic lupus erythematosus
(SLE) that affects approximately 40% of patients. Pathogenic immune complexes that are …

[HTML][HTML] Pregnancy-associated atypical hemolytic uremic syndrome: a systematic review

M Gupta, S Govindappagari… - Obstetrics & Gynecology, 2020 - journals.lww.com
OBJECTIVE: To evaluate disease presentation, diagnosis, treatment, and clinical outcomes
in pregnancy-associated atypical hemolytic uremic syndrome (aHUS). DATA SOURCES: We …

Atypical hemolytic uremic syndrome: new challenges in the complement blockage era

AI Avila Bernabeu, T Cavero Escribano, M Cao Vilarino - Nephron, 2020 - karger.com
Atypical hemolytic uremic syndrome (aHUS) is a rare cause of thrombotic microangiopathy
(TMA), characterized by microangiopathic hemolytic anemia, consumptive …

Eculizumab treatment for renal failure in a pediatric patient with COVID-19

R Mahajan, M Lipton, L Broglie, NG Jain, NS Uy - Journal of Nephrology, 2020 - Springer
While there are increasing reports of acute kidney injury among hospitalized adults with
COVID-19, there is still limited information on renal complications associated with COVID-19 …

[HTML][HTML] Consensus regarding diagnosis and management of atypical hemolytic uremic syndrome

H Lee, E Kang, HG Kang, YH Kim, JS Kim… - The Korean Journal …, 2020 - ncbi.nlm.nih.gov
Thrombotic microangiopathy (TMA) is defined by specific clinical characteristics, including
microangiopathic hemolytic anemia, thrombocytopenia, and pathologic evidence of …

Typical and atypical hemolytic uremic syndrome in the critically ill

CL Manrique-Caballero… - Critical Care …, 2020 - criticalcare.theclinics.com
Hemolytic uremic syndrome (HUS) is a thrombotic microangiopathy (TMA) defined by the
clinical triad of thrombocytopenia, microangiopathic hemolytic anemia (MAHA) and renal …

An update in drug-induced thrombotic microangiopathy

T Chatzikonstantinou, M Gavriilaki… - Frontiers in …, 2020 - frontiersin.org
Drug-induced thrombotic microangiopathy (DITMA) is a life-threatening complication that is
often under-recognized and under-reported (1). Despite recent systematic reviews …

Therapeutic lessons to be learned from the role of complement regulators as double-edged sword in health and disease

ECW De Boer, AG Van Mourik, I Jongerius - Frontiers in immunology, 2020 - frontiersin.org
The complement system is an important part of the innate immune system, providing a
strong defense against pathogens and removing apoptotic cells and immune complexes …

Targeting complement in severe coronavirus disease 2019 to address microthrombosis

F Valga, N Vega-Diaz, M Macia, T Monzon… - Clinical Kidney …, 2020 - academic.oup.com
There is no approved therapy for coronavirus disease 2019 (COVID-19)[severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection], and the number of worldwide …

Profiles of coagulation and fibrinolysis activation-associated molecular markers of atypical hemolytic uremic syndrome in the acute phase

S Sakurai, H Kato, Y Yoshida, Y Sugawara… - … of atherosclerosis and …, 2020 - jstage.jst.go.jp
Aim: Atypical hemolytic uremic syndrome (aHUS), characterized by thrombotic
microangiopathy (TMA), is a genetic, life-threatening disease which needs many differential …