Studies have shown that the prevalence of RAS and BRAF mutations may differ by tumor
sidedness among metastatic colorectal cancer (mCRC) patients. Both mutation status and …

Colorectal cancer (CRC) remains a devastating human malignancy with poor prognosis. Of
the various factors, immune evasion mechanisms play pivotal roles in CRC progression and …

Bone metastasis is known as a poor prognostic factor in colorectal cancer (CRC), but its
clinical manifestations and outcomes are uncertain. CRC with bone metastasis was …

Metastasis remains the principle cause of mortality for breast cancer and presents a critical
challenge because secondary lesions are often refractory to conventional treatments. While …

Background Mutant KRAS tumors are purported to metastasize differently than wild-type
KRAS tumors. The biological heterogeneity of tumors from different parts of the colon are …

RAS GTPases are fundamental regulators of development and drivers of an extraordinary
number of human cancers. RAS oncoproteins constitutively signal through downstream …

Objective: Mutation in KRAS gene is one of the most common genetic changes among
patients with colorectal cancer (CRC), which is observed in 30-45% of cases. This study …

Cancer metastasis, particularly multiple metastatic cancer, is a significant event that affects
patient prognosis. However, single metastasis can be treated by partial resection, although …

Background The oncological benefit of complete metastasectomy for simultaneous
colorectal liver and lung metastases (SLLM) have not been fully investigated. Methods …

While liver metastases in colorectal cancer patients are common, only a small proportion of
patients with colorectal liver metastases (CRLM) are considered resectable at presentation …