Morpholine is a heterocycle featured in numerous approved and experimental drugs as well
as bioactive molecules. It is often employed in the field of medicinal chemistry for its …

Histamine has been one of the most studied substances in medicine, playing a major role in
diverse (patho) physiological processes. It elicits its multifaceted modulatory functions by …

In the present review, we will discuss the recent advances in the understanding of the role of
histamine and histamine receptors in cancer biology. The controversial role of the …

Fluorescence/luminescence-based techniques play an increasingly important role in the
development of test systems for the characterization of future drug candidates, especially in …

Inflammatory mediators may have a role in various lower urinary tract disorders. Histamine is
known to induce significant increases in both the tension and frequency of spontaneous …

The histamine H 2 receptor (H2R) plays an important role in the regulation of gastric acid
secretion. Therefore, it is a main drug target for the treatment of gastroesophageal reflux or …

Currently employed histamine H2 receptor (H2R) radioligands possess several drawbacks,
for example, high non-specificity, insurmountable binding, or short half-life. We report the …

H1 nonsedating antihistamines, such as desloratadine, are first-line treatment options for
chronic spontaneous urticaria (CSU). However, desloratadine induces various degrees of …

The present work analyzes the clinical and psychopathological implications of
hyperhistaminosis, starting from the general consideration that, despite the recent scarcity of …

In this work, we studied the mechanisms of classical activation and inactivation of signal
transduction by the histamine H3 receptor, a 7-helix transmembrane bundle G-Protein …