Background The homeostasis of metal ions, such as iron, copper, zinc and calcium, in the
brain is crucial for maintaining normal physiological functions. Studies have shown that …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Cells have developed elaborate quality-control mechanisms for proteins and organelles to
maintain cellular homeostasis. Such quality-control mechanisms are maintained by …

Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Autophagy is a major, conserved cellular pathway by which cells deliver cytoplasmic
contents to lysosomes for degradation. Genetic studies have revealed extensive links …

Tauopathies are neurodegenerative diseases associated with accumulation of abnormal tau
protein in the brain. Patient iPSC-derived neuronal cell models replicate disease-relevant …

Macroautophagy/autophagy deficit induces intracellular MAPT/tau accumulation, the
hallmark pathology in Alzheimer disease (AD) and other tauopathies; however, the reverse …

Background Lysosomes digest extracellular material from the endocytic pathway and
intracellular material from the autophagic pathway. This process is performed by the resident …

MicroRNAs are small non-coding nucleic acids that are responsible for regulating the gene
expression by binding to the coding region and 3'and 5'un-translated region of target …

The autophagy lysosomal pathway (ALP) is a major mechanism for degrading intracellular
macromolecules. The catabolic products can then be used by the cell for energy or as …