Depression development: From lifestyle changes to motivational deficits

D Schulz - Behavioural brain research, 2020 - Elsevier
Until now, depression research has taken a surprisingly narrow approach to modelling the
disease, mainly focusing on some form of psychomotor retardation within a mechanistic …

Comparison of acute treatment with delayed-onset versus rapid-acting antidepressants on effort-related choice behaviour

S Griesius, JR Mellor, ESJ Robinson - Psychopharmacology, 2020 - Springer
Rationale Reward-related impairments are common in major depressive disorder (MDD)
and may contribute to the loss of interest in pleasurable activities. A novel approach to …

Investigating hormone-induced changes in affective state using the affective bias test in male and female rats

JK Hinchcliffe, M Mendl, ESJ Robinson - Psychoneuroendocrinology, 2020 - Elsevier
Recent clinical and pre-clinical research suggests that affective biases may play an
important role in the development and perpetuation of mood disorders. Studies in animals …

All-trans Retinoic Acid-induced Abnormal Hippocampal Expression of Synaptic Genes SynDIG1 and DLG2 is Correlated with Anxiety or Depression-Like Behavior in …

XY Qin, H Fang, QH Shan, CC Qi, JN Zhou - International Journal of …, 2020 - mdpi.com
Clinical reports suggest a potential link between excess retinoids and development of
depression. Although it has been shown that all-trans retinoic acid (ATRA) administration …