Amiloride is a potassium retaining diuretic and natriuretic which acts by reversibly blocking
luminal epithelial sodium channels (ENaCs) in the late distal tubule and collecting duct …

In the Guidelines, differentiation between optimal and essential standards were not always
possible, and were made in sections where it was most practical and sensible. The …

Члены Рабочей группы: Арутюнов ГП, Баранова ЕИ, Барбараш ОЛ, Бойцов СА,
Вавилова ТВ, Виллевальде СВ, Галявич АС, Глезер МГ, Гринева ЕН, Гринштейн ЮИ …

Chronic kidney disease (CKD) causes salt-sensitive hypertension that is often resistant to
treatment and contributes to the progression of kidney injury and cardiovascular disease. A …

Background Distal diuretics are considered less effective than loop diuretics in CKD.
However, data to support this perception are limited. Methods To investigate whether distal …

Diabetes and osteoporosis are two common diseases with different complications. Despite
different therapeutic strategies, managing these diseases and reducing their burden have …

Background Diabetic nephropathy is a common diabetes mellitus complication associated
with hypertension, proteinuria, and excretion of urinary plasmin that activates the epithelial …

The purpose of this review was to discuss the role of sodium and inflammation in the
pathophysiology of hypertension and the observed different hemodynamic effects of drugs …

Background Spironolactone, a cheap effective diuretic used to manage hypertension and
heart failure, also has anti-androgenic effects through its non-selective binding to steroid …

Российское медицинское общество по артериальной гипертонии. Рекомендации по
ведению больных артериальной гипертонией с метаболическими нарушениями и …