Plasticity of innate lymphoid cell subsets

SM Bal, K Golebski, H Spits - Nature Reviews Immunology, 2020 - nature.com
Innate lymphoid cells (ILCs) are important for tissue homeostasis and for the initiation of
immune responses. Based on their transcriptional regulation and cytokine profiles, ILCs can …

Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases

Y Jiao, L Wu, ND Huntington, X Zhang - Frontiers in immunology, 2020 - frontiersin.org
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …

[HTML][HTML] Tissue-specific features of innate lymphoid cells

I Meininger, A Carrasco, A Rao, T Soini, E Kokkinou… - Trends in …, 2020 - cell.com
Although the function of the circulating immune cell compartment has been studied in detail
for decades, limitations in terms of access and cell yields from peripheral tissues have …

Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity

CSN Klose, D Artis - Cell research, 2020 - nature.com
The multifaceted organization of the immune system involves not only patrolling
lymphocytes that constantly monitor antigen-presenting cells in secondary lymphoid organs …

Adult chronic rhinosinusitis

C Bachert, B Marple, RJ Schlosser, C Hopkins… - Nature reviews Disease …, 2020 - nature.com
Chronic rhinosinusitis (CRS) occurs in> 10% of the adult population in Europe and the USA
and can be differentiated into CRS without nasal polyps and CRS with nasal polyps …

[HTML][HTML] Single-cell analysis of RORα tracer mouse lung reveals ILC progenitors and effector ILC2 subsets

M Ghaedi, ZY Shen, M Orangi… - Journal of Experimental …, 2020 - rupress.org
Lung group 2 innate lymphoid cells (ILC2s) drive allergic inflammation and promote tissue
repair. ILC2 development is dependent on the transcription factor retinoic acid receptor …

Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current knowledge

C Bachert, M Humbert, NA Hanania… - European …, 2020 - Eur Respiratory Soc
While immunoglobulin (Ig) E is a prominent biomarker for early-onset, its levels are often
elevated in non-allergic late-onset asthma. However, the pattern of IgE expression in the …

Interleukin-33 induces the enzyme tryptophan hydroxylase 1 to promote inflammatory group 2 innate lymphoid cell-mediated immunity

AL Flamar, CSN Klose, JB Moeller, T Mahlakõiv… - Immunity, 2020 - cell.com
Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue
homeostasis. Two distinct subsets of ILC2s have been described: steady-state natural ILC2s …

Innate lymphoid cell composition associates with COVID‐19 disease severity

M García, E Kokkinou… - Clinical & …, 2020 - Wiley Online Library
Objectives The role of innate lymphoid cells (ILCs) in coronavirus disease 2019 (COVID‐
19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is …

Differential expression of the transcription factor GATA3 specifies lineage and functions of innate lymphoid cells

C Zhong, M Zheng, K Cui, AJ Martins, G Hu, D Li… - Immunity, 2020 - cell.com
Lymphoid tissue inducer (LTi) cells are regarded as a subset of innate lymphoid cells (ILCs).
However, these cells are not derived from the ILC common progenitor, which generates …