Understanding the impact of antibiotic perturbation on the human microbiome

DJ Schwartz, AE Langdon, G Dantas - Genome medicine, 2020 - Springer
The human gut microbiome is a dynamic collection of bacteria, archaea, fungi, and viruses
that performs essential functions for immune development, pathogen colonization …

Gut microbiota resilience: definition, link to health and strategies for intervention

SK Dogra, J Doré, S Damak - Frontiers in microbiology, 2020 - frontiersin.org
The gut microbiota is a new frontier in health and disease. Not only many diseases are
associated with perturbed microbiota, but an increasing number of studies point to a cause …

Gut bacteria composition drives primary resistance to cancer immunotherapy in renal cell carcinoma patients

L Derosa, B Routy, M Fidelle, V Iebba, L Alla, E Pasolli… - European urology, 2020 - Elsevier
Background The development of immune checkpoint blockade (ICB) has revolutionized the
clinical outcome of renal cell carcinoma (RCC). Nevertheless, improvement of durability and …

Metagenome-wide association analysis identifies microbial determinants of post-antibiotic ecological recovery in the gut

KR Chng, TS Ghosh, YH Tan, T Nandi, IR Lee… - Nature ecology & …, 2020 - nature.com
Loss of diversity in the gut microbiome can persist for extended periods after antibiotic
treatment, impacting microbiome function, antimicrobial resistance and probably host health …

Role of carbon monoxide in host–gut microbiome communication

CP Hopper, LK De La Cruz, KV Lyles… - Chemical …, 2020 - ACS Publications
Nature is full of examples of symbiotic relationships. The critical symbiotic relation between
host and mutualistic bacteria is attracting increasing attention to the degree that the gut …

Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

B Seelbinder, J Chen, S Brunke, R Vazquez-Uribe… - Microbiome, 2020 - Springer
Background Antibiotic treatment has a well-established detrimental effect on the gut
bacterial composition, but effects on the fungal community are less clear. Bacteria in the …

Keystone taxa indispensable for microbiome recovery

SM Gibbons - Nature microbiology, 2020 - nature.com
Keystone taxa indispensable for microbiome recovery | Nature Microbiology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Gut resistomes, microbiota and antibiotic residues in Chinese patients undergoing antibiotic administration and healthy individuals

Y Duan, Z Chen, L Tan, X Wang, Y Xue, S Wang… - Science of the Total …, 2020 - Elsevier
Human gut microbiota is an important reservoir of antibiotic resistance genes (ARGs).
Although dysbacteriosis after the antibiotic course has been previously observed in the …

A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects

CC Mefferd, SS Bhute, JR Phan, JV Villarama, DM Do… - Msystems, 2020 - Am Soc Microbiol
Clostridioides difficile (formerly Clostridium difficile) infection (CDI) can result from the
disruption of the resident gut microbiota. Western diets and popular weight-loss diets drive …

Each additional day of antibiotics is associated with lower gut anaerobes in neonatal intensive care unit patients

AM Rooney, K Timberlake, KA Brown… - Clinical Infectious …, 2020 - academic.oup.com
Background Discontinuation of inappropriate antimicrobial therapy is an important target for
stewardship intervention. The drug and duration-dependent effects of antibiotics on the …